• Publications
  • Influence
Intrinsically disordered protein.
Proteins can exist in a trinity of structures: the ordered state, the molten globule, and the random coil. The five following examples suggest that native protein structure can correspond to any ofExpand
  • 1,142
  • 89
  • PDF
Retinoic acid regulates sex-specific timing of meiotic initiation in mice.
In mammals, meiosis is initiated at different time points in males and females, but the mechanism underlying this difference is unknown. Female germ cells begin meiosis during embryogenesis. InExpand
  • 741
  • 81
  • PDF
Plzf is required in adult male germ cells for stem cell self-renewal
Adult germline stem cells are capable of self-renewal, tissue regeneration and production of large numbers of differentiated progeny. We show here that the classical mouse mutant luxoid affects adultExpand
  • 706
  • 57
  • PDF
Postmeiotic Sex Chromatin in the Male Germline of Mice
In mammals, the X and Y chromosomes are subject to meiotic sex chromosome inactivation (MSCI) during prophase I in the male germline, but their status thereafter is currently unclear. An abundance ofExpand
  • 339
  • 41
Androgens regulate the permeability of the blood-testis barrier.
Within the mammalian testis, specialized tight junctions between somatic Sertoli cells create basal and apical polarity within the cells, restrict movement of molecules between cells, and separateExpand
  • 314
  • 30
  • PDF
The Murine Testicular Transcriptome: Characterizing Gene Expression in the Testis During the Progression of Spermatogenesis1
Abstract One of the most promising applications of microarrays is the study of changes in gene expression associated with the growth and development of mammalian tissues. The testis provides anExpand
  • 435
  • 24
DMRT1 prevents female reprogramming in the postnatal mammalian testis.
Sex in mammals is determined in the fetal gonad by the presence or absence of the Y chromosome gene Sry, which controls whether bipotential precursor cells differentiate into testicular Sertoli cellsExpand
  • 273
  • 22
The central role of Sertoli cells in spermatogenesis.
  • M. Griswold
  • Medicine, Biology
  • Seminars in cell & developmental biology
  • 1 August 1998
Sertoli cells are the somatic cells of the testis that are essential for testis formation and spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via direct contactExpand
  • 684
  • 21
  • PDF
The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells.
The switch from mitosis to meiosis is a unique feature of germ cell development. In mammals, meiotic initiation requires retinoic acid (RA), which activates meiotic inducers, including Stra8, but howExpand
  • 225
  • 19
Expression of Stimulated by Retinoic Acid Gene 8 (Stra8) in Spermatogenic Cells Induced by Retinoic Acid: An In Vivo Study in Vitamin A-Sufficient Postnatal Murine Testes1
Abstract Vitamin A is required for male fertility and normal spermatogenesis. Retinoic acid (RA), an active metabolite of vitamin A, is necessary for spermatogonial maturation and proper entry ofExpand
  • 194
  • 16
  • PDF