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The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance.
- R. Dobson, M. Griffin, G. Jameson, J. Gerrard
- ChemistryActa Crystallographica Section D: Biological…
- 1 August 2005
The general architecture of the active site is found to be consistent with previously determined structures, but with some important differences, and a re-evaluation of the dimer-dimer interface reveals a more extensive network of interactions than first thought.
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax
Using Brazilian and Thai clinical isolates, data show that TfR1-PvRBP2b invasion pathway is critical for the recognition of reticulocytes during P. vivax invasion.
Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I
- Y. Wong, K. Binger, G. Howlett, M. Griffin
- BiologyProceedings of the National Academy of Sciences
- 19 January 2010
This systematic study of fibrillar formation by full-length apoA-I represents the first demonstration that methionine oxidation can induce amyloid fibril formation.
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Evidence is provided that the transition of human MLKL from a monomeric state to a tetramer is essential for necroptosis signalling.
Characterisation of the First Enzymes Committed to Lysine Biosynthesis in Arabidopsis thaliana
DHDPR from A. thaliana (At-D HDPR2) has similar specificity for both NADH and NADPH during catalysis, and has tighter binding of substrate than has previously been reported.
Small Oligomers of Ribulose-bisphosphate Carboxylase/Oxygenase (Rubisco) Activase Are Required for Biological Activity
A variety of techniques are used to show that Rubisco activase forms a wide range of structures in solution, ranging from monomers to much higher order species, and that the distribution of these species is highly dependent on protein concentration.
Dihydrodipicolinate synthase (DHDPS) from Escherichia coli displays partial mixed inhibition with respect to its first substrate, pyruvate.
The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6.
- T. Putoczki, R. Dobson, M. Griffin
- Biology, MedicineActa crystallographica. Section D, Biological…
- 1 September 2014
Comparisons show important differences between the two cytokines and it is suggested that IL-11 engages GP130 differently to IL-6, and these data offer insight into the binding interactions ofIL-11 with each of its receptors and the structural mechanisms underlying agonist and antagonist variants of the protein.
Notch ligand delta-like1: X-ray crystal structure and binding affinity.
- N. Kershaw, Nicole L. Church, M. Griffin, C. Luo, T. Adams, A. Burgess
- BiologyBiochemical Journal
- 15 May 2015
The X-ray crystal structure of the extracellular domain of the Notch ligand delta-like ligand-1 (Dll-1) is determined, which incorporates the N-terminal C2 domain, receptor-binding DSL domain and the first six EGF-like repeats, which form a highly extended conformation, confirmed by analytical ultracentrifugation.
A repeat sequence domain of the ring‐exported protein‐1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking
It is shown that inducible knockdown of REX1 causes stacking of Maurer's cleft cisternae without disrupting the organization of the knob‐associated histidine‐rich protein at the RBC membrane, which is predicted to form a largely α‐helical structure, with a repetitive charge pattern in the repeat sequence domain, providing potential insights into the role of REx1 in Maurers' cleft sculpting.