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Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control
TLDR
Two distinct networks typically coactivated during functional MRI tasks are identified, anchored by dorsal anterior cingulate and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an “executive-control network” that links dorsolateral frontal and parietal neocortices. Expand
Functional connectivity in the resting brain: A network analysis of the default mode hypothesis
TLDR
This study constitutes, to the knowledge, the first resting-state connectivity analysis of the default mode and provides the most compelling evidence to date for the existence of a cohesive default mode network. Expand
Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
TLDR
A goodness-of-fit analysis applied at the individual subject level suggests that activity in the default-mode network may ultimately prove a sensitive and specific biomarker for incipient AD. Expand
Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus
TLDR
The findings provide cross-modality confirmation of PET studies demonstrating increased thalamic and subgenual cingulate activity in major depression and suggest that a quantitative, resting-state fMRI measure could be used to guide therapy in individual subjects. Expand
Decoding subject-driven cognitive states with whole-brain connectivity patterns.
TLDR
It is demonstrated that free-streaming subject-driven cognitive states can be decoded using a novel whole-brain functional connectivity analysis, and this approach should enable decoding a myriad of subject- driven cognitive states from brief imaging data samples. Expand
Resting-state functional connectivity reflects structural connectivity in the default mode network.
TLDR
The results demonstrate that resting-state functional connectivity reflects structural connectivity and that combining modalities can enrich the understanding of these canonical brain networks. Expand
Network Analysis of Intrinsic Functional Brain Connectivity in Alzheimer's Disease
TLDR
This study provides new evidence that there is disrupted organization of functional brain networks in AD, and suggests that these network measures may be useful as an imaging-based biomarker to distinguish AD from healthy aging. Expand
Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease.
TLDR
The findings suggest that behavioural variant frontotemporal dementia and Alzheimer's disease lead to divergent network connectivity patterns, consistent with known reciprocal network interactions and the strength and deficit profiles of the two disorders. Expand
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
TLDR
It is shown that five different neurodegenerative syndromes cause circumscribed atrophy within five distinct, healthy, human intrinsic functional connectivity networks, and a direct link between intrinsic connectivity and gray matter structure is discovered. Expand
Default-Mode Activity during a Passive Sensory Task: Uncoupled from Deactivation but Impacting Activation
TLDR
Time-series analysis of default-mode activity provides a measure of the degree to which a task engages a subject and whether it is sufficient to interrupt the processes presumably cognitive, internally generated, and involving episodic memorymediated by the default- mode network. Expand
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