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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
TLDR
It is demonstrated that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors, which triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene. Expand
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
TLDR
The effects of dominant-interfering or constitutively activated forms of various components of the JNK-p38 and ERK signaling pathways demonstrated that activation of JNK and p38 and concurrent inhibition of ERK are critical for induction of apoptosis in these cells. Expand
Cellular survival: a play in three Akts.
TLDR
The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed. Expand
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
TLDR
It is shown that growth factor activation of the PI3'K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival. Expand
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
TLDR
One way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance. Expand
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
TLDR
The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes. Expand
Widespread transcription at neuronal activity-regulated enhancers
TLDR
It is revealed that a widespread mechanism of enhancer activation involves RNAPII binding and eRNA synthesis, which occurs specifically at enhancers that are actively engaged in promoting mRNA synthesis. Expand
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
TLDR
It is found that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene and suggests that the deregulation of this process may underlie the pathology of RT T. Expand
Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt
TLDR
Findings suggest that in the developing nervous system, Akt is a critical mediator of growth factor-induced neuronal survival. Expand
A brain-specific microRNA regulates dendritic spine development
TLDR
It is shown that a brain-specific microRNA, miR-134>, is localized to the synapto-dendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines—postsynaptic sites of excitatory synaptic transmission. Expand
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