- M. Gray
- BiologyCold Spring Harbor Perspectives in Biology
New data continue to reshape views regarding mitochondrial evolution, particularly raising the question of whether the mitochondrion originated after the eukaryotic cell arose, as assumed in the classical endosymbiont hypothesis, or whether this organelle had its beginning at the same time as the cell containing it.
The tree of eukaryotes.
Mitochondrial genomes: anything goes.
The origin and early evolution of mitochondria
Complete sequences of numerous mitochondrial, many prokaryotic, and several nuclear genomes are now available and confirm that the mitochondrial genome originated from a eubacterial ancestor but raise questions about the evolutionary antecedents of the mitochondrial proteome.
An ancestral mitochondrial DNA resembling a eubacterial genome in miniature
Feature of gene content together with eubacterial characteristics of genome organization and expression not found before in mitochondrial genomes indicate that R. americana mtDNA more closely resembles the ancestral proto-mitochondrial genome than any other mtDNA investigated to date.
Mitochondrial genome evolution and the origin of eukaryotes.
Defining more precisely the alpha-proteobacterial ancestry of the mitochondrial genome, and the contribution of the endosymbiotic event to the nuclear genome, will be essential for a full understanding of the origin and evolution of the eukaryotic cell as a whole.
Pseudouridine in RNA: What, Where, How, and Why
These studies demonstrate that pseudouridylation of RNA confers an important selective advantage in a natural biological context.
Strikingly Bacteria-Like and Gene-Rich Mitochondrial Genomes throughout Jakobid Protists
Phylogenetic analysis with mtDNA-encoded proteins strongly supports monophyly of jakobids with Andalucia as the deepest divergence, however, it remains unclear which α-proteobacterial group is the closest mitochondrial relative.
The Closest Unicellular Relatives of Animals
Unique mitochondrial genome architecture in unicellular relatives of animals
- G. Burger, L. Forget, Yun Zhu, M. Gray, B. Lang
- BiologyProceedings of the National Academy of Sciences…
- 24 January 2003
It is posited that the distinct compaction characteristic of metazoan mitochondrial genomes occurred simultaneously with the emergence of a multicellular body plan in the animal lineage.