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Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
TLDR
It is shown that Cnp1, which encodes 2′,3′-cyclic nucleotide phosphodiesterase in oligodendrocytes, is essential for axonal survival but not for myelin assembly, and the chief function of glia in supporting axonal integrity can thus be completely uncoupled from its function in maintaining compact myelin. Expand
Four‐kilobase sequence of the mouse CNP gene directs spatial and temporal expression of lacZ in transgenic mice
TLDR
Results provide strong evidence that cis‐acting regulatory elements, necessary to direct spatial and temporal expression of the transgene in oligodendrocytes, are located within the 4‐kb 5′‐flanking sequence of the mouse CNP gene. Expand
Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein
TLDR
It is proposed that CNP is an important component of the cytoskeletal machinery that directs process outgrowth in OLs and tubulin is a major CNP-interacting protein. Expand
Identification and Characterization of Early Glial Progenitors Using a Transgenic Selection Strategy
TLDR
This novel approach definitively establishes that the β-gal-positive cells identifiedin vivo are glial progenitors, as defined by their ability to survive antibiotic selection and differentiate into OLs or SCs in vitro. Expand
Mitochondrial localization of CNP2 is regulated by phosphorylation of the N-terminal targeting signal by PKC: Implications of a mitochondrial function for CNP2 in glial and non-glial cells
TLDR
CNP2 is imported into mitochondria and the targeting signal cleaved, yielding a mature, truncated form similar in size to CNP1, indicating that it is localized specifically to mitochondria in non-myelinating cells. Expand
Loss of membrane targeting of Vangl proteins causes neural tube defects.
TLDR
This study reports a common mechanism for both the naturally occurring Lp (S464N) and a novel ENU-induced mutation Lp(m2Jus)(R259L) and shows that the S464N and R259L variants stably expressed in polarized MDCK kidney cells fail to reach the plasma membrane, their site for biological function. Expand
CNP overexpression induces aberrant oligodendrocyte membranes and inhibits MBP accumulation and myelin compaction
TLDR
Data support a functional role for CNP during oligodendrocyte membrane expansion and indicate, for the first time, that CNP may help target MBP to compact myelin. Expand
Structural Evidence That Brain Cyclic Nucleotide Phosphodiesterase Is a Member of the 2H Phosphodiesterase Superfamily*
TLDR
NMR titrations of the CNP catalytic domain with inhibitors and kinetic studies of site-directed mutants reveal a protein conformational change that occurs upon binding, placing CNP in the superfamily of 2H phosphodiesterases that contain two tetrapeptide HX(T/S)X motifs. Expand
Overexpression of 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase in Transgenic Mice Alters Oligodendrocyte Development and Produces Aberrant Myelination
TLDR
Results indicate that CNP is an early expressed regulator of cellular events that culminate in CNS myelination, and ODC that overexpress CNP appear to mature earlier in development, resulting in earlier maximum gene expression for myelin basic proteins and proteolipid protein. Expand
Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption.
TLDR
It is found that combining pemetrexed with GMX1777 produced a synergistic therapeutic benefit in A549 and H1299 NSCLC cells in vitro and in a mouse A549 xenograft model of lung cancer. Expand
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