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In vivo delivery of recombinant viruses to the fetal murine cochlea: transduction characteristics and long-term effects on auditory function.
Congenital hearing deficits can be caused by a variety of genetic and acquired conditions. Complete reversal of deficits in the peripheral auditory system may require delivery of corrective genes toExpand
Enhanced evoked response amplitudes in the inferior colliculus of the chinchilla following acoustic trauma
Evoked response amplitude-level functions were measured from electrodes in the inferior colliculus of the chinchilla before and after exposure to a 2 kHz pure tone of 105 dB SPL. The exposureExpand
Interaction of cisplatin and noise on the peripheral auditory system
The potentiation of cisplatin ototoxicity by noise was explored in the chinchilla. The effects of exposure to cisplatin alone, noise alone or concurrent exposure to both agents were compared in termsExpand
Alterations in microvasculature are associated with atrophy of the stria vascularis in quiet-aged gerbils
Age-related changes in the integrity of the stria vascularis and its microvasculature were assessed in whole mount preparations of the gerbil cochlear lateral wall. Small focal regions containing fewExpand
Synergistic interactions of noise and other ototraumatic agents.
The following is a review of the literature on interaction of noise and other agents, both ototraumatic and nonototraumatic. A short description of the anatomical effects of exposure to intense soundExpand
Noise-induced changes in gene expression in the cochleae of mice differing in their susceptibility to noise damage
The molecular mechanisms underlying the vast differences between individuals in their susceptibility to noise-induced hearing loss (NIHL) are unknown. The present study demonstrated that the effectsExpand
Laminin α2-Mediated Focal Adhesion Kinase Activation Triggers Alport Glomerular Pathogenesis
It has been known for some time that laminins containing α1 and α2 chains, which are normally restricted to the mesangial matrix, accumulate in the glomerular basement membranes (GBM) of Alport mice,Expand
Expression and Functional Phenotype of Mouse ERG K+ Channels in the Inner Ear: Potential Role in K+ Regulation in the Inner Ear
An outcome of the intricate K+ regulation in the cochlear duct is the endocochlear potential (EP), ∼80 mV, the “battery” that runs hair-cell transduction; however, the detailed molecular mechanismsExpand
Age-related hearing loss: current research
Purpose of reviewSignificant changes in population demographics with respect to age have taken place, and this pattern is expected to continue. The aging of the population underscores the importanceExpand
Hyperpigmentation of chinchilla stria vascularis following acoustic trauma.
This report describes morphological alterations of the chinchilla stria vascularis seen 30 days after exposure to impulse noise. The observed changes included a dramatic increase in strial melaninExpand