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A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III.
Rnt1 endoribonuclease, the yeast homolog of RNAse III, plays an important role in the maturation of a diverse set of RNAs. The enzymatic activity requires a conserved catalytic domain, while RNA… Expand
Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex
- Arnaud Hecker, Raffaele Lopreiato, +4 authors H. van Tilbeurgh
- Medicine, Biology
- The EMBO journal
- 3 September 2008
The EKC/KEOPS yeast complex is involved in telomere maintenance and transcription. The Bud32p and kinase‐associated endopeptidase 1 (Kae1p) components of the complex are totally conserved in eukarya… Expand
The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases
- N. Leulliot, M. T. Bohnsack, M. Graille, D. Tollervey, H. van Tilbeurgh
- Biology, Medicine
- Nucleic acids research
- 26 November 2007
Emg1 was previously shown to be required for maturation of the 18S rRNA and biogenesis of the 40S ribosomal subunit. Here we report the determination of the crystal structure of Emg1 at 2 A… Expand
Zinc induces structural reorganization of gelatin binding domain from human fibronectin and affects collagen binding.
- M. Graille, M. Pagano, T. Rose, Michèle Reboud Ravaux, H. van Tilbeurgh
- Biology, Medicine
- 9 June 2010
Fibronectin is a modular extracellular matrix protein involved in cell adhesion, cell motility, wound healing, and maintenance of cell morphology. It is composed of multiple repeats of three distinct… Expand
The structure of an archaeal homodimeric ligase which has RNA circularization activity
- Mark A Brooks, L. Meslet-Cladiére, +4 authors H. van Tilbeurgh
- Chemistry, Medicine
- Protein science : a publication of the Protein…
- 1 August 2008
The genome of Pyrococcus abyssi contains two open reading frames encoding proteins which had been previously predicted to be DNA ligases, Pab2002 and Pab1020. We show that while the former is indeed… Expand
Immunization with heat-killed Toxoplasma gondii stimulates an early IFN-gamma response and induces protection against virulent murine malaria.
In this study, we describe protection of BALB/c mice by immunization with heat-killed T. gondii tachyzoites against infection with Plasmodium yoelii 17XL which causes cerebral malaria and death in… Expand
Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol
Type II DNA topoisomerases have been classified into two families, Topo IIA and Topo IIB, based on structural and mechanistic dissimilarities. Topo IIA is the target of many important antibiotics and… Expand
Structure of viral flavin-dependant thymidylate synthase ThyX
Mechanism of activation of methyltransferases involved in translation by the Trm112 ‘hub’ protein
The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase.
Radicicol derivatives are currently investigated as promising antitumoral drugs because they inhibit the activity of the molecular chaperone heat shock protein (HSP90), causing the destabilization… Expand