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Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial.
IMPORTANCE High-dose intravenous administration of sodium selenite has been proposed to improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided antimicrobial therapy may… Expand
Diagnose und Therapie der Sepsis
ZusammenfassungNach neuesten Erhebungen des vom BMBF geförderten Kompetenznetzwerkes Sepsis (SepNet) erkranken in Deutschland pro Jahr 75.000 Einwohner (110 von 100.000) an einer schweren Sepsis bzw.… Expand
Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats
IntroductionDopexamine may be a therapeutic option to improve hepatosplanchnic perfusion in sepsis. To investigate this possibility, we administered dopexamine in an experimental sepsis model in… Expand
A large outbreak of multiresistant Pseudomonas aeruginosa strains in north-eastern Germany.
- B. Panzig, G. Schröder, F. Pitten, M. Gründling
- Medicine, Biology
- The Journal of antimicrobial chemotherapy
- 1 March 1999
Multiply-resistant Pseudomonas aeruginosa were first detected in north-eastern Germany at the end of 1996; since then they have been isolated predominantly from patients in intensive care units.… Expand
Excessive Tryptophan Catabolism Along the Kynurenine Pathway Precedes Ongoing Sepsis in Critically Ill Patients
It has recently been shown that an increased plasma level of the tryptophan catabolite kynurenine is an early indicator for the development of sepsis in major trauma patients. We examined the… Expand
Propranolol selectively blocks the enhanced parietal old/new effect during long-term recollection of unpleasant pictures: A high density ERP study
Evidence from both animal and human research suggests that the formation of emotional memories is triggered by the beta-adrenergic system. To confirm whether modulation of central beta-adrenergic… Expand
Effects of coagulation factor XIII on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation in experimental endotoxemia
IntroductionThe objective of this study was to determine the effects of the administration of the coagulation factor XIII (F XIII) on intestinal functional capillary density, leukocyte adherence and… Expand
Effects of activated protein C on the mesenteric microcirculation and cytokine release during experimental endotoxemia
- C. Lehmann, R. Scheibe, +8 authors D. Pavlović
- Canadian journal of anaesthesia = Journal…
- 1 March 2008
Purpose: Activated protein C (APC) is the first anti-inflammatory drug to be approved for the treatment of severe sepsis. However, the underlying mechanisms are not completely elucidated. Therefore,… Expand
Continuing chronic beta-blockade in the acute phase of severe sepsis and septic shock is associated with decreased mortality rates up to 90 days
Background There is growing evidence that beta-blockade may reduce mortality in selected patients with sepsis. However, it is unclear if a pre-existing, chronic oral beta-blocker therapy should be… Expand
Response of the rat intestinal microcirculation to experimental endotoxemia is attenuated by ampicillin but not by its derivative KKP723.
- M. Gründling, C. Lehmann, +10 authors U. Lindequist
- Clinical hemorheology and microcirculation
KKP723 (KKP), a derivative of ampicillin, is a newly developed beta-lactam antibiotic. Using an experimental endotoxemia model, the intestinal microcirculation in four groups of animals were… Expand