• Publications
  • Influence
Pax‐3, a novel murine DNA binding protein expressed during early neurogenesis.
We describe the isolation and characterization of Pax‐3, a novel murine paired box gene expressed exclusively during embryogenesis. Pax‐3 encodes a 479 amino acid protein with an Mr of 56 kdExpand
  • 885
  • 79
Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord.
Members of the paired box (Pax) gene family are expressed in discrete regions of the developing central nervous system, suggesting a role in neural patterning. In this study, we describe theExpand
  • 386
  • 30
  • PDF
Fate of Midbrain Dopaminergic Neurons Controlled by the Engrailed Genes
Deficiencies in neurotransmitter-specific cell groups in the midbrain result in prominent neural disorders, including Parkinson's disease, which is caused by the loss of dopaminergic neurons of theExpand
  • 321
  • 30
  • PDF
PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development.
Members of the PAX family of transcription factors are candidates for controlling cell identity in the spinal cord. We have morphologically analyzed cells that express one of these transcriptionExpand
  • 205
  • 26
Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm.
Pax-3 is a paired-type homeobox gene that is specifically expressed in the dorsal and posterior neural tube. We have investigated inductive interactions that initiate Pax-3 transcript expression inExpand
  • 177
  • 23
  • PDF
Expression of Pax-3 in the lateral neural plate is dependent on a Wnt-mediated signal from posterior nonaxial mesoderm.
During early patterning of the vertebrate neuraxis, the expression of the paired-domain transcription factor Pax-3 is induced in the lateral portions of the posterior neural plate via posteriorizingExpand
  • 197
  • 20
  • PDF
Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons.
During early development, multiple classes of interneurons are generated in the spinal cord including association interneurons that synapse with motor neurons and regulate their activity. Very littleExpand
  • 169
  • 19
  • PDF
PAX 2 is expressed in multiple spinal cord interneurons , including a population of EN 1 + interneurons that require PAX 6 for their development
Members of the PAX family of transcription factors are candidates for controlling cell identity in the spinal cord. We have morphologically analyzed cells that express one of these transcriptionExpand
  • 91
  • 7
  • PDF
Pax: a murine multigene family of paired box-containing genes.
A murine multigene family has been identified that shares a conserved sequence motif, the paired box, with developmental control and tissue-specific genes of Drosophila. To date five murine pairedExpand
  • 413
  • 6
Analysis of the Pax-3 gene in the mouse mutant splotch.
In a linkage analysis of Pax-3 and splotch no recombinations were found in 117 backcross mice. Molecular analysis of Pax-3 in three alleles of splotch shows a number of significant alterations to theExpand
  • 131
  • 4