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CD26: A Multifunctional Integral Membrane and Secreted Protein of Activated Lymphocytes
- M. Gorrell, V. Gysbers, G. McCaughan
- Biology, MedicineScandinavian journal of immunology
- 1 September 2001
The focus of this review is the structure and function of CD 26 and the influence of its ligand binding activity on T‐cell proliferation and the T cell costimulatory activity of CD26.
Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage
- T. Oravecz, M. Pall, +6 authors M. Norcross
- Chemistry, MedicineThe Journal of experimental medicine
- 1 December 1997
The results indicate that CD26-mediated processing together with cell activation–induced changes in receptor expression provides an integrated mechanism for differential cell recruitment and for the regulation of target cell specificity of RANTES, and possibly other chemokines.
Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8.
- C. Abbott, D. M. Yu, E. Woollatt, G. Sutherland, G. McCaughan, M. Gorrell
- Biology, MedicineEuropean journal of biochemistry
- 1 October 2000
DPP8, a novel human postproline dipeptidyl aminopeptidase that is homologous to DPPIV and FAP is described and a potential role for DPP8 in T-cell activation and immune function is suggested.
Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders.
- M. Gorrell
- Biology, MedicineClinical science
- 1 April 2005
The functional interactions of DPIV and FAP with extracellular matrix confer roles for these proteins in cancer biology and DPIV has become a novel target for Type II diabetes therapy.
Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition.
The preponderance of data suggests that such D PP-8 and DPP-9 enzyme inhibition is probably without clinical consequence, and the implications of Dpp-4 inhibition in the treatment of Type 2 diabetes are likely to be minimal.
The dipeptidyl peptidase IV family in cancer and cell biology
This article examines, in detail, the current understanding of the biological involvement of the dipeptidyl peptidase IV gene family and their overall potential as therapeutic targets.
3-dimensional imaging of collagen using second harmonic generation.
- G. Cox, E. Kable, Allan S. Jones, I. Fraser, F. Manconi, M. Gorrell
- MedicineJournal of structural biology
This work shows how its unique triple-helix structure and extremely high level of crystallinity make it exceptionally efficient in generating the second harmonic of incident light leads to a novel mode of microscopy of immediate practical significance in medicine and biology.
Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity.
- Katerina Ajami, C. Abbott, G. McCaughan, M. Gorrell
- Biology, MedicineBiochimica et biophysica acta
- 13 July 2004
Novel data on the sizes and tissue distribution of human and rat gene products and the peptidase activity of the DPIV-related gene DP9 is presented and it is shown that only DP9 and DP8 have exclusively cytoplasmic localization and onlyDP9, DP8, fibroblast activation protein (FAP) and DPIV have peptid enzyme activity.
Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX‐2 human stellate cell line
Findings further support a pro‐fibrogenic role for FAP by indicating that FAP has important nonenzymatic functions that in chronic liver injury may facilitate tissue remodeling through FAP‐mediated enhancement of HSC cell adhesion, migration, and apoptosis.
Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression
- N. Shackel, P. H. McGuinness, C. Abbott, M. Gorrell, G. McCaughan
- Biology, MedicineGut
- 1 October 2001
Many genes implicated in intrahepatic inflammation, fibrosis, and regeneration were upregulated in PBC cirrhosis, in particular, increased expression of a number of Drosophila homologues was seen.