CD26: A Multifunctional Integral Membrane and Secreted Protein of Activated Lymphocytes
- M. Gorrell, V. Gysbers, G. McCaughan
- Biology, MedicineScandinavian Journal of Immunology
- 1 September 2001
The focus of this review is the structure and function of CD 26 and the influence of its ligand binding activity on T‐cell proliferation and the T cell costimulatory activity of CD26.
Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage
The results indicate that CD26-mediated processing together with cell activation–induced changes in receptor expression provides an integrated mechanism for differential cell recruitment and for the regulation of target cell specificity of RANTES, and possibly other chemokines.
Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders.
- M. Gorrell
- Biology, ChemistryClinical science
- 1 April 2005
The functional interactions of DPIV and FAP with extracellular matrix confer roles for these proteins in cancer biology and DPIV has become a novel target for Type II diabetes therapy.
Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8.
- C. Abbott, D. M. Yu, E. Woollatt, G. Sutherland, G. McCaughan, M. Gorrell
- BiologyEuropean Journal of Biochemistry
- 1 October 2000
DPP8, a novel human postproline dipeptidyl aminopeptidase that is homologous to DPPIV and FAP is described and a potential role for DPP8 in T-cell activation and immune function is suggested.
The dipeptidyl peptidase IV family in cancer and cell biology
This article examines, in detail, the current understanding of the biological involvement of the dipeptidyl peptidase IV gene family and their overall potential as therapeutic targets.
Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition.
The preponderance of data suggests that such D PP-8 and DPP-9 enzyme inhibition is probably without clinical consequence, and the implications of Dpp-4 inhibition in the treatment of Type 2 diabetes are likely to be minimal.
Covid-19 and co-morbidities: a role for Dipeptidyl Peptidase 4 (DPP4) in disease severity?
DPP4 upregulation may be a determinant of Covid-19 disease severity, which creates interest regarding the use of gliptins in management of Covd-19, and increased plasma DPP4 is a predictor of the onset of metabolic syndrome.
Faculty Opinions recommendation of Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26.
- M. Gorrell
- Faculty Opinions – Post-Publication Peer Review…
- 13 July 2020
3-dimensional imaging of collagen using second harmonic generation.
Diabetes and nonalcoholic Fatty liver disease: a pathogenic duo.
The pathogenic links between NAFLD and diabetes are examined by exploring the epidemiological evidence in humans and also through newer animal models, and the potential role of preventive and therapeutic approaches in the setting of diabetes is examined.