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A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer
TLDR
Multivariable Mendelian randomization performed in a two-sample approach using summary data on 6,034 oral/oropharyngeal cases and 6,585 controls from a recent genome-wide association study demonstrates strong evidence for an independent causal effect of smoking on oral/ oropharynGEal cancer and an independent causative effect of alcohol consumption when controlling for smoking.
Aerosol generating procedures: are they of relevance for transmission of SARS-CoV-2?
Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study
TLDR
Limited evidence is found for a role of cholesterol-lowering in OC and OPC risk, suggesting previous observational results may have been confounded, and limited evidence of a causal effect of genetically-proxied LDL-C lowering using HMGCR, NPC1L1, CETP or other circulating lipid traits on either OC or OPCrisk.
Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization
TLDR
Evaluated aspects of sexual behaviour in relation to the risk of OPC, using genetic variants associated with age at first sex (AFS) and number of sexual partners (NSP) to perform Mendelian randomization (MR) analyses found evidence for correlated pleiotropy in the genetic instruments for sexual behaviour.
Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: a Mendelian randomization study
TLDR
Limited evidence is found of a causal effect of genetically-proxied LDL-C lowering using HMGCR, NPC1L1, CETP or other circulating lipid traits on either OC or OPC risk, suggesting previous observational results may have been confounded.
An observational analysis of risk factors associated with symptomatic third molar teeth
TLDR
Symptomatic third molars are common in this age group, with over half of the participants reporting pain or other symptoms, and female participants had greater odds for third molar pain, swelling and treatment.
Metabolic disorders and the risk of head and neck cancer: a protocol for a systematic review and meta-analysis
TLDR
A systematic review of cohort studies, reporting a risk of incident HNSCC, and a combined risk effect across studies will be calculated using meta-analysis, although depending on the heterogeneity in study design, exposure and outcome reporting this may not be possible.
Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization
TLDR
Evidence for correlated pleiotropy is found despite using genetic variants strongly related sexual behaviour traits in large-scale GWAS, which emphasizes a need for multivariable approaches and the triangulation of evidence when performing MR of complex behavioural traits.
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