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Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon alfa administration.
- L. Capuron, G. Pagnoni, Andrew H. Miller
- Biology, PsychologyArchives of General Psychiatry
- 1 October 2012
Findings that inflammatory stimuli, including inflammatory cytokines, such as interferon alfa, alter basal ganglia activity and behavior in association with significant changes in presynaptic striatal dopamine function consistent with decreased dopamine synthesis or release are replicated.
Silencing of CXCR4 blocks breast cancer metastasis.
- Zhongxing Liang, Y. Yoon, J. Votaw, M. Goodman, L. Williams, H. Shim
- BiologyCancer Research
- 1 February 2005
It is shown that direct injection of a pool of naked small interfering RNA (siRNA) duplexes can prevent tumorigenesis in an animal model, suggesting a novel preventive and therapeutic strategy for cancer management.
Synthesis and evaluation of [18F]1-amino-3-fluorocyclobutane-1-carboxylic acid to image brain tumors.
- T. Shoup, J. Olson, M. Goodman
- Medicine, ChemistryJournal of nuclear medicine : official…
- 1 February 1999
The amino acid FACBC can be radiofluorinated for clinical use and is a potential PET tracer for tumor imaging, evaluated for its potential in tumor localization.
Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-Dihydroxyflavone in the Binding and Activation of the TrkB Receptor*
It is shown that 7,8-DHF and BDNF exhibit different TrkB activation kinetics in which TrkB maturation may be implicated, and its agonistic effect may be mediated by neuronal development and maturation.
Detection of recurrent prostate carcinoma with anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid PET/CT and 111In-capromab pendetide SPECT/CT.
Anti-3-(18)F-FACBC PET/CT was more sensitive than (111)In-capromab pendetide SPECT/CT in the detection of recurrent prostate carcinoma and is highly accurate in the differentiation of prostatic from extraprostatic disease.
Recurrent prostate cancer detection with anti-3-[18F]FACBC PET/CT: comparison with CT
- O. Odewole, F. Tade, D. Schuster
- Medicine, PhysicsEuropean Journal of Nuclear Medicine and…
- 18 April 2016
The diagnostic performance of fluciclovine PET/CT in recurrent prostate cancer is superior to that of CT and fluco-PET/CT provides better delineation of prostatic from extraprostatic recurrence.
Functional brain imaging alterations in acne patients treated with isotretinoin.
This study suggests that isotretinoin treatment is associated with changes in brain functioning, a brain area known to mediate symptoms of depression.
Radioiodinated 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid: a useful new agent to evaluate myocardial fatty acid uptake.
- F. F. Knapp, M. Goodman, A. P. Callahan, G. Kirsch
- Chemistry, BiologyJournal of nuclear medicine : official…
- 1 April 1986
The greater myocardial retention and higher heart:blood ratios observed with DMIPP in comparison with both the 3-monomethyl-(BMIPP) and unbranched (IPP) analogs suggest that [123I]DMIPP is an excellent candidate for clinical evaluation of regional energy substrates (fatty acid) uptake.
The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta)
A preliminary study of anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid for the detection of prostate cancer.
FACBC PET is believed to be useful not only for the visualization of human PCa but also for differentiating between PCa and inflammation and betweenPCa and BHP.