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Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
Hematopoietic stem cells (HSC) are multipotent cells that reside in the bone marrow and replenish all adult hematopoietic lineages throughout the lifetime of the animal. While experimenting withExpand
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Effects of an Rb mutation in the mouse
The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb isExpand
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A distinct "side population" of cells with high drug efflux capacity in human tumor cells.
A subset of stem cells, termed the "side population" (SP), has been identified in several tissues in mammalian species. These cells maintain a high efflux capability for antimitotic drugs. We haveExpand
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Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells.
Myocyte loss in the ischemically injured mammalian heart often leads to irreversible deficits in cardiac function. To identify a source of stem cells capable of restoring damaged cardiac tissue, weExpand
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Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species
We previously described a method for isolating murine hematopoietic stem cells capable of reconstituting lethally irradiated recipients, which depends solely on dual-wavelength flow cytometricExpand
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Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Using highly purified hematopoietic stem cells from mice aged 2 to 21 mo, weExpand
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Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.
The traditional view of hematopoiesis has been that all the cells of the peripheral blood are the progeny of a unitary homogeneous pool of hematopoietic stem cells (HSCs). Recent evidence suggestsExpand
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Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population.
Mammary epithelium can functionally regenerate upon transplantation. This renewal capacity has been classically ascribed to the function of a multipotent mammary gland stem cell population, which hasExpand
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Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.
To investigate the cell-intrinsic aging mechanisms that erode the function of somatic stem cells during aging, we have conducted a comprehensive integrated genomic analysis of young and aged cells.Expand
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mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert
A unique property of many adult stem cells is their ability to exist in a non-cycling, quiescent state. Although quiescence serves an essential role in preserving stem cell function until the stemExpand
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