M. González-Andrade

Publications53
h-index12
Citations380
Highly Influential Citations10
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α-glucosidase inhibitors from Brickellia cavanillesii.
An aqueous extract from the aerial parts of Brickellia cavanillesii attenuated postprandial hyperglycemia in diabetic mice during oral glucose and sucrose tolerance tests. Experimental type-II DM was… Expand
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(+)-Ascosalitoxin and vermelhotin, a calmodulin inhibitor, from an endophytic fungus isolated from Hintonia latiflora.
Chemical investigation of the endophytic MEXU 26343, isolated from the medicinal plant Hintonia latiflora, yielded the known polyketide vermelhotin (1) and a new salicylic aldehyde derivative,… Expand
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Mutational and genetic determinants of λ6 light chain amyloidogenesis
Approximately 25% of the λ6 light chains have glycine rather than arginine at position 25, which is an allelic variant of the IGLV6‐57 (6a) locus. The Gly25 variant has been shown to decrease the… Expand
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Gnaphaliin A and B relax smooth muscle of guinea‐pig trachea and rat aorta via phosphodiesterase inhibition
Objectives  To explore the relaxant mechanism of action of gnaphaliin A and gnaphaliin B in guinea‐pig trachea and rat aorta, and to investigate the theoretical and experimental phosphodiesterase… Expand
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Potent Anti-Calmodulin Activity of Cyclotetradepsipeptides Isolated from Isaria fumosorosea Using a Newly Designed Biosensor
Seven cyclotetradepsipeptides, namely beauverolides C (1), F (2), I (3), Ja (4), L (5), M (6), and N (7), were isolated from the entomopathogenic fungus Isaria fumosorosea. The beauverolides were… Expand
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Effect of N-Benzylpiperazine, Its Metabolite N-Benzylethylenediamine, and Its Disubstituted Analogue N,N'-Dibenzylpiperazine on the Acquisition, Formation, and Consolidation of Memory in Mice
Background:N-benzylpiperazine (BZP) belongs to a class of piperazine derivatives (PZDs) that have emerged as recreational drugs. These compounds increase the release of dopamine and serotonin. BZP… Expand
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Calmodulin inhibitors from the fungus Emericella sp.
Two new xanthones identified as 15-chlorotajixanthone hydrate (1) and 14-methoxytajixanthone (2) were isolated from an Emericella sp. strain 25379 along with shamixanthone (3) and tajixanthone… Expand
  • 30
Development of the fluorescent biosensor hCalmodulin (hCaM)L39C-monobromobimane(mBBr)/V91C-mBBr, a novel tool for discovering new calmodulin inhibitors and detecting calcium.
A novel, sensible, and specific fluorescent biosensor of human calmodulin (hCaM), namely hCaM L39C-mBBr/V91C-mBBr, was constructed. The biosensor was useful for detecting ligands with opposing… Expand
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α-Glucosidase Inhibitors from Salvia circinata.
A dried infusion prepared from the aerial parts of Salvia circinata did not provoke acute toxicity in mice (LD50 > 5 g/kg). This infusion showed poor hypoglycemic and antihyperglycemic effects… Expand
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An alternative assay to discover potential calmodulin inhibitors using a human fluorophore-labeled CaM protein.
This article describes the development of a new fluorescent-engineered human calmodulin, hCaM M124C-mBBr, useful in the identification of potential calmodulin (CaM) inhibitors. An hCaM mutant… Expand
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