Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines
- C. Baker, W. Phelps, V. Lindgren, M. Braun, M. Gonda, P. Howley
- BiologyJournal of Virology
- 1 April 1987
Transcription analysis revealed expression of the HPV-16 genome in each of these two cervical carcinoma cell lines, albeit at significantly different levels, and preliminary mapping of the viral RNA with subgenomic strand-specific probes indicated that viral transcription appeared to be derived primarily from the E6 and E7 ORFs.
Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS.
- J. Schüpbach, M. Popovič, R. Gilden, M. Gonda, M. Sarngadharan, R. Gallo
- Biology, MedicineScience
- 4 May 1984
Another subgroup of HTLV, designated HTLV-III, has now been isolated from many patients with AIDS and pre-AIDS and is shown to be a true member of the HTLV family.
Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species.
A new species of Helicobacter is reported that selectively and persistently colonizes the hepatic bile canaliculi of mice, causing a morphologically distinctive pattern of chronic, active hepatitis and associated with a high incidence of hepatocellular neoplasms in infected animals.
Nucleotide sequence and genome organization of biologically active proviruses of the bovine immunodeficiency-like virus.
The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes
Cloned probes from the Harvey and Kirsten strains of murine sarcoma virus encode enzymatically and serologically related p21 src proteins, which suggest that cellular p21 sarc genes constitute a divergent family of vertebrate genes that can regulate the growth of cells.
Simple, rapid, quantitative, syncytium-forming microassay for the detection of human immunodeficiency virus neutralizing antibody.
Results indicate that there are no detectable nonsyncytial variants in standard HIV-I stocks, andherent within this system is a flexible method for studying various kinetics of antibody/virus interactions, as well as blocking and interference studies with any candidate antiviral compounds.
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.
- M. Park, M. Dean, K. Kaul, M. Braun, M. Gonda, G. V. Vande Woude
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 September 1987
It is concluded that the MET protooncogene is a cell-surface receptor for an as-yet-unknown ligand that is most homologous with the human insulin receptor and v-abl.
Characterization and molecular cloning of a bovine lentivirus related to human immunodeficiency virus
The sequence data and serologic analyses together show that this bovine retrovirus is a novel lentivirus related to HIV and other lentiviruses, and it is proposed that this virus be tentatively named Bovine immunodeficiency-like virus (BIV) to reflect its genetic relationship and biological similarity to HIV.
Phase I single-dose study of intracavitary-administered iodine-131-TM-601 in adults with recurrent high-grade glioma.
Dosimetry and biodistribution from this first trial suggest that phase II studies of 131I-TM-601 are indicated and may have an antitumoral effect in patients with recurrent glioma.
Human immunodeficiency virus-like particles produced by a vaccinia virus expression vector.
- V. Karacostas, K. Nagashima, M. Gonda, B. Moss
- BiologyProceedings of the National Academy of Sciences…
- 1 November 1989
The production of noninfectious virus-like particles by expression vectors should be useful for biochemical studies and could provide a safe source of material for the development of vaccines.