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Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines
Transcription analysis revealed expression of the HPV-16 genome in each of these two cervical carcinoma cell lines, albeit at significantly different levels, and preliminary mapping of the viral RNA with subgenomic strand-specific probes indicated that viral transcription appeared to be derived primarily from the E6 and E7 ORFs. Expand
Simple, rapid, quantitative, syncytium-forming microassay for the detection of human immunodeficiency virus neutralizing antibody.
Results indicate that there are no detectable nonsyncytial variants in standard HIV-I stocks, andherent within this system is a flexible method for studying various kinetics of antibody/virus interactions, as well as blocking and interference studies with any candidate antiviral compounds. Expand
Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species.
A new species of Helicobacter is reported that selectively and persistently colonizes the hepatic bile canaliculi of mice, causing a morphologically distinctive pattern of chronic, active hepatitis and associated with a high incidence of hepatocellular neoplasms in infected animals. Expand
Nucleotide sequence and genome organization of biologically active proviruses of the bovine immunodeficiency-like virus.
The complete nucleotide sequences and translations of major open reading frames (ORF) of two distinct, infectious, proviral molecular clones of the bovine immunodeficiency-like virus (BIV), obtained from a single virus isolation, were determined and compared and suggest that BIV displays extensive genomic variation. Expand
The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes
Cloned probes from the Harvey and Kirsten strains of murine sarcoma virus encode enzymatically and serologically related p21 src proteins, which suggest that cellular p21 sarc genes constitute a divergent family of vertebrate genes that can regulate the growth of cells. Expand
Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS.
Another subgroup of HTLV, designated HTLV-III, has now been isolated from many patients with AIDS and pre-AIDS and is shown to be a true member of the HTLV family. Expand
Human immunodeficiency virus-like particles produced by a vaccinia virus expression vector.
The production of noninfectious virus-like particles by expression vectors should be useful for biochemical studies and could provide a safe source of material for the development of vaccines. Expand
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.
It is concluded that the MET protooncogene is a cell-surface receptor for an as-yet-unknown ligand that is most homologous with the human insulin receptor and v-abl. Expand
Characterization of clones of HIV-1 infected HuT 78 cells defective in gag gene processing and of SIV clones producing large amounts of envelope glycoprotein.
Single-cell clones of HIV-1 (FRE-3) or SIV/Mne infected HuT 78 cells were obtained by plating dilutions of virally infected HuT 78 cells on a monolayer of sheep choroid plexus cells in 96-wellExpand
Characterization and molecular cloning of a bovine lentivirus related to human immunodeficiency virus
The sequence data and serologic analyses together show that this bovine retrovirus is a novel lentivirus related to HIV and other lentiviruses, and it is proposed that this virus be tentatively named Bovine immunodeficiency-like virus (BIV) to reflect its genetic relationship and biological similarity to HIV. Expand