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Recruitment and derecruitment during acute respiratory failure: an experimental study.
We aimed to elucidate the relationships between pleural (Ppl), esophageal (Pes), and superimposed gravitational pressures in acute lung injury, and to understand the mechanisms of recruitment andExpand
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Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. VII. Mortality and selected nonfatal events with insulin treatment.
The University Group Diabetes Program is a long-term prospective clinical trial designed to evaluate the effects of various hypoglycemic agents on vascular complications in patients with asymptomaticExpand
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Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. 3. Clinical implications of UGDP results.
"Field (clinical) trials are indispensable. They will continue to be an ordeal. They lack glamour, they strain our resources and our patience, and they protract the moment of truth to excruciatingExpand
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IN APRIL 1943 Shaw Dunn, Sheehan and McLetchie announced their discovery that alloxan, the ureide of mesoxalic acid, causes necrosis of the pancreatic islet cells. In the meantime, the diabetogenicExpand
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Gender-based differences in children with sepsis and ARDS: The ESPNIC ARDS Database Group
Male gender predisposes to severe sepsis and septic shock. This effect has been ascribed to higher levels of testosterone. The ESPNIC ARDS database was searched, to determine if there was evidence ofExpand
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Hyperglycemia and glycosuria due to thiazide derivatives administered in diabetes mellitus.
THE purpose of this communication is to call attention to the fact that the thiazides may cause aggravation of pre-existent diabetes mellitus, or the manifestation of the disease in predisposed per...
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Abstract A substance capable of inducing free fatty acid release was sought in the blood of pregnant women. The rat epididymal fat pad was used for bioassay. Sera from 12 of 13 pregnant patientsExpand
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Failure of Protein to Protect Against Cholesterol Atherogenesis in Underfed Rabbits
Summary 1. Study of effect of protein on development of experimental atherosclerosis on blood lipids and lipoproteins, in underfed rabbits with supplementary cholesterol, was performed. 2.Expand
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Acute Nature of Alloxan Damage.*
Summary Clamping of a portion of the dog's pancreas during and for the period of 1 to 6 min after the injection of a diabetogenic dose of alloxan will protect that portion of the gland from alloxanExpand
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Glucose intolerance in the progeny of rats treated with single subdiabetogenic dose of alloxan.
Abstract A single subdiabetogenic dose of alloxan administered to the weanling rat induces a persistent state of carbohydrate intolerance (latent diabetes) which does not progress to frank diabetesExpand
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