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Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.
A novel fungal metabolite, apicidin, that exhibits potent, broad spectrum antiprotozoal activity in vitro against Apicomplexan parasites has been identified and is also orally and parenterally active in vivo against Plasmodium berghei malaria in mice. Expand
Firefly "femmes fatales" acquire defensive steroids (lucibufagins) from their firefly prey.
It is found that by feeding on Photinus males, Photuris females gain more than nutrients, and acquire defensive steroidal pyrones called lucibufagins, which are contained in Photinus but which photuris fireflies are unable to produce on their own. Expand
Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase
Equisetin and a novel opposite stereochemical homolog, phomasetin, are isolated from Fusarium heterosporum and a Phoma sp. Expand
Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities.
The isolation and structure elucidation of new apicidins from two Fusarium species, temperature-dependent NMR studies of apicIDin, NMR and molecular modeling based conformation of the 12-membered macrocyclic ring, and selected chemical modifications of Apicidin have been detailed in this paper. Expand
Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK.
A resorcylic acid lactone, L-783,277, isolated from a Phoma sp. (ATCC 74403) which came from the fruitbody of Helvella acetabulum, is a potent and specific inhibitor of MEK (Map kinase kinase).Expand
New potently bioactive alkaloids from Crinum erubescens.
Antimalarial bioassay-guided fractionation of the swamp lily Crinum erubescens led to the isolation of four compounds with potent antiplasmodial activity, which were identified as the known alkaloid hippadine, which was inactive against Plasmodium falciparum. Expand
Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud.
A bioassay-guided fractionation and chemical investigation of Amaryllis belladonna Steud resulted in the isolation and identification of the new crinane alkaloid 1,4-dihydroxy-3-methoxy powellan and the structures were elucidated by interpretation of combined HR-ESIMS, CD and 2D NMR spectroscopic data. Expand
Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus.
Kibdelomycin is the first truly novel bacterial type II topoisomerase inhibitor with potent antibacterial activity discovered from natural product sources in more than six decades. Expand
Red Cochineal Dye (Carminic Acid): Its Role in Nature
The behavior of an unusual predator is described—the carnivorous caterpillar of a pyralid moth (Laetilia coccidivora)—which is undeterred by carminic acid and feeds on cochineals, and has the remarkable habit of utilizing the ingested carminal acid for defensive purposes of its own. Expand
Maxikdiol: a novel dihydroxyisoprimane as an agonist of Maxi-K channels
Maxi-K (large-conductance calcium-activated potassium)channels are a family of proteins which are thought to play an important role in controlling the contractility of airway smooth muscle. MaxikdiolExpand