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- Publications
- Influence
Tau pathology and neurodegeneration
- M. Spillantini, M. Goedert
- Medicine
- The Lancet Neurology
- 1 June 2013
The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and filamentous tau protein is at the centre of many human neurodegenerative diseases, collectively referred to as… Expand
Cryo-EM structures of tau filaments from Alzheimer's disease
- A. Fitzpatrick, Benjamin Falcon, +7 authors S. Scheres
- Chemistry
- 13 July 2017
- 425
- 40
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
- F. Clavaguera, H. Akatsu, +10 authors M. Tolnay
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 20 May 2013
Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer’s disease, tangle-only dementia, Pick disease, argyrophilic… Expand
The switch of tau protein to an Alzheimer‐like state includes the phosphorylation of two serine‐proline motifs upstream of the microtubule binding region.
- J. Biernat, E. Mandelkow, +7 authors M. Goedert
- Medicine, Biology
- The EMBO journal
- 1 April 1992
The paired helical filaments (PHFs) of Alzheimer's disease consist mainly of the microtubule‐associated protein tau. PHF tau differs from normal human brain tau in that it has a higher Mr and a… Expand
Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein
- M. Goedert
- Biology, Medicine
- Science
- 7 August 2015
Converging paradigms in neurodegeneration Parkinson's disease and Alzheimer's disease are progressive neurodegenerative diseases with increasing prevalence in our aging populations. Recent evidence… Expand
A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity
- Z. Ahmed, Jane Cooper, +14 authors M. O'Neill
- Biology, Medicine
- Acta Neuropathologica
- 16 February 2014
Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of Alzheimer’s disease, progressive supranuclear palsy, Pick’s disease and other sporadic neurodegenerative… Expand
Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau (*)
- P. Seubert, M. Mawal-Dewan, +8 authors V. Lee
- Medicine, Chemistry
- The Journal of Biological Chemistry
- 11 August 1995
Paired helical filaments (PHFs) are the major structural elements of Alzheimer's disease neurofibrillary lesions, and these filaments are formed from hyperphosphorylated brain tau known as PHF-tau.… Expand
“Prion‐Like” Templated Misfolding in Tauopathies
- F. Clavaguera, I. Lavenir, Ben Falcon, S. Frank, M. Goedert, M. Tolnay
- Biology, Medicine
- Brain pathology
- 1 May 2013
The soluble microtubule‐associated protein tau forms hyperphosphorylated, insoluble and filamentous inclusions in a number of neurodegenerative diseases referred to as “tauopathies.” In Alzheimer's… Expand
A novel mutation at position +12 in the intron following Exon 10 of the tau gene in familial frontotemporal dementia (FTD‐Kumamoto)
- M. Yasuda, J. Takamatsu, +13 authors Chikako Tanaka
- Biology, Medicine
- Annals of neurology
- 1 April 2000
Exonic and intronic mutations in the tau gene cause familial frontotemporal dementia and parkinsonism linked to chromosome 17. Here, we describe a new mutation, consisting of a C‐to‐T transition at… Expand
A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies
- M. Grazia Spillantini, H. Yoshida, +5 authors J. Brown
- Biology, Medicine
- Annals of neurology
- 1 December 2000
Familial dementia with swollen achromatic neurons and corticobasal inclusion bodies is a neurodegenerative disease that resembles corticobasal degeneration. It is characterized by the presence of… Expand