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Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.
TLDR
The epidemiology of Klebsiella pneumoniae carbapenemases across continents is summarized, issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control are discussed.
CTX-M: changing the face of ESBLs in Europe.
TLDR
Dramatic shifts have occurred in the prevalence and types of extended-spectrum beta-lactamases (ESBLs) in Europe, and changing patterns present major therapeutic and infection control challenges, with the public health intervention points unclear.
Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe.
TLDR
Rapid identification of colonized or infected patients and screening of carriers is possible, and will probably be effective for prevention of a scenario of endemicity, as now reported for extended-spectrum β-lactamase producers in all European countries.
Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts.
TLDR
A consultation of experts from 31 countries set out to identify the gaps in diagnostic and response capacity, to index the magnitude of carbapenem-non-susceptibility across Europe using a novel five-level staging system, and to provide elements of a strategy to combat this public health issue in a concerted manner.
Identification and screening of carbapenemase-producing Enterobacteriaceae.
TLDR
Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies, and the detection of carriers still relies mostly on the use of screening culture media.
Comparison of Multiple-Locus Variable-Number Tandem-Repeat Analysis with Pulsed-Field Gel Electrophoresis, spa Typing, and Multilocus Sequence Typing for Clonal Characterization of Staphylococcus
TLDR
The results suggest that MLVA may be reliable in shorter-term S. aureus epidemiological studies, including analyses of outbreaks and hospital-to-hospital strain transmission events and those performing routine microbiological analyses within medical centers.
Cefotaxime-Resistant EnterobacteriaceaeIsolates from a Hospital in Warsaw, Poland: Identification of a New CTX-M-3 Cefotaxime-Hydrolyzing β-Lactamase That Is Closely Related to the CTX-M-1/MEN-1
TLDR
The results suggest that CTX-M genes have been spread among different species of the familyEnterobacteriaceae in the hospital and that the CTx-M-3-expressing C. freundii strain causing routine urinary tract infections has been maintained for a relatively long time in thehospital environment.
Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues.
TLDR
Criteria must be established for which isolates should be suspected and screened for carbapenemase production, and for which tests (phenotypic and/or genotypic) should be adopted for confirmation of the resistance mechanism, and strategies should be devised for surveillance of carbapanemase producers in order to enable the implementation of effective surveillance programmes.
Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study.
TLDR
The development of a consistent sampling framework and the results of the first structured survey on the occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in European hospitals are reported.
Interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in intensive care units: an interrupted time series study and cluster randomised trial
TLDR
In the context of a sustained high level of compliance to hand hygiene and chlorhexidine bathings, screening and isolation of carriers do not reduce acquisition rates of multidrug-resistant bacteria, whether or not screening is done with rapid testing or conventional testing.
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