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Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa).
Bisphosphonates (BPs) are pyrophosphate analogues in which the oxygen in P-O-P has been replaced by a carbon, resulting in a metabolically stable P-C-P structure. Pamidronate (1b, Novartis), aExpand
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Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways.
The gp130-dependent cytokines, which signal through at least two intracellular pathways, regulate osteoclast and osteoblast formation. To define their roles in regulating bone mass, we analyzed miceExpand
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Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response.
Interleukin-1 (IL-1) has been implicated in the development and progression of a variety of acute and chronic inflammatory diseases. Due to its pro-inflammatory and tissue-degrading activities, IL-1Expand
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A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo.
The tyrosine kinase Src has been implicated in the process of osteoclast-mediated bone resorption. Here, we describe a novel class of Src inhibitors, substitutedExpand
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Mechanical and radiological assessment of the influence of rhTGFβ‐3 on bone regeneration in a segmental defect in the ovine tibia: Pilot study
Limitations in the use of autologous bone graft, which is the gold standard therapy in bone defect healing, drive the search for alternative treatments. In this study the influence of rhTGFβ‐3 onExpand
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Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors.
Peripheral blood progenitor cells (PBPCs) are increasingly used for autografting after high-dose chemotherapy. One advantage of PBPCs over the use of autologous bone marrow would be a reduced risk ofExpand
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Long-Term Zoledronic Acid Treatment Increases Bone Structure and Mechanical Strength of Long Bones of Ovariectomized Adult Rats
Zoledronic acid (ZOL) is a highly potent heterocyclic bisphosphonate which has been shown to inhibit bone resorption in short-term experiments in young growing animals. In this investigation we haveExpand
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Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis.
OBJECTIVE To study the effect of zoledronic acid (ZA) on synovial inflammation, structural joint damage, and bone metabolism in rats during the effector phase of collagen-induced arthritis (CIA). Expand
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Pharmacological control of prostaglandin and thromboxane release from macrophages
MACROPHAGES have a key role in mediating inflammatory reactions1. They appear in large numbers in inflammed tissue, and on contact with irritant particles release comparatively large quantities ofExpand
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Mechanisms of action of anti-inflammatory drugs.
Abstract 1. 1. Current and older hypotheses on the mode of action of nonsteroid anti-inflammatory drugs (NSAID) are reviewed. 2. 2. It is shown that even the most convincing concept that NSAID exertExpand
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