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A rat model of bone cancer pain
TLDR
The induction of bone cancer in the rat by the syngeneic MRMT‐1 mammary tumour cell line provides a valid pre‐clinical model for pain associated with bone metastases and suggests a reasonable time window for evaluation of anti‐nociceptive agents between day 14 and 20 after cancer cell inoculation in this model.
Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa).
TLDR
The results of the clinical trials indicate that low doses of Zoledronic acid are both efficacious and safe for the treatment of tumor-induced hypercalcemia, Paget's disease of bone, osteolytic metastases, and postmenopausal osteoporosis.
Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways.
TLDR
GP130 is essential for normal bone growth and trabecular bone mass, with balanced regulation depending on selective activation of STAT1/3 and SHP2/ras/MAPK, respectively, the latter pathway can directly inhibit osteoclastogenesis in vivo.
Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response.
TLDR
Injection of anti-IL-1 beta starting at day 3 totally prevented both the development of arthritis and the associated increase of the acute phase protein serum amyloid P (SAP).
A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo.
TLDR
A novel class of Src inhibitors, substituted 5,7-diphenyl-pyrrolo[2,3-d]pyrimidines, is described and characterized and partly prevented bone loss and microarchitectural changes in young ovariectomized rats, showing that the protective effect on bone was exerted via the inhibition of bone resorption.
Mechanical and radiological assessment of the influence of rhTGFβ‐3 on bone regeneration in a segmental defect in the ovine tibia: Pilot study
TLDR
It is concluded that rhTGFβ‐3 has a promoting effect on bone regeneration, but under the conditions of this study this effect does not reach the potential of autologous cancellous bone graft transplantation.
Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors.
TLDR
There is a high proportion of patients with circulating tumor cells under steady-state conditions, and in addition a substantial risk of concomitant tumor cell recruitment upon mobilization of PBPCs, particularly in stage IV breast cancer patients with bone marrow infiltration.
Long-Term Zoledronic Acid Treatment Increases Bone Structure and Mechanical Strength of Long Bones of Ovariectomized Adult Rats
TLDR
The data show that mechanical testing detects improvements of functional bone quality following low dose bisphosphonate treatment which are not identified by standard DXA measurements of BMD.
Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors [see comments]
TLDR
There is a high proportion of patients with circulating tumor cells under steady-state conditions, and in addition a substantial risk of concomitant tumor cell recruitment upon mobilization of PBPCs, particularly in stage IV breast cancer patients with bone marrow infiltration.
Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis.
TLDR
Single doses of ZA strikingly reduced focal bone erosions and juxtaarticular trabecular bone loss, although synovitis was mildly exacerbated, and targeting osteoclasts with ZA may be an effective strategy for preventing structural joint damage in rheumatoid arthritis.
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