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DNA damage and ubiquitinated neuronal inclusions in the substantia nigra and striatum of mice following MDMA (ecstasy)
It is found that MDMA, besides a decrease of nigrostriatal DA innervation and 5HT loss, produces neuronal inclusions within nigral and intrinsic striatal neurons consisting of multi-layer ubiquitin-positive whorls extending to the nucleus of the cell.
Forensic Entomology and the Estimation of the Minimum Time Since Death in Indoor Cases
It is shown that if sealed environment may delay, the insect arrival dirty houses may create the environment where sarcosaprophagous insects are already present, and it is shown the ability of these species in indoor body colonization.
High-performance liquid chromatography for the quantitative determination of the urinary metabolites of toluene, xylene, and styrene
SummaryA new high-pressure liquid chromatography (HPLC) method for simultaneous quantitative determination of the urinary metabolites of toluene, m-xylene, and styrene (hippuric acid,
MDMA Induces Caspase‐3 Activation in the Limbic System but not in Striatum
Investigation of whether treatment with MDMA produces activation of the caspase‐3 enzyme, which is part of an enzymatic pathway involved in cell death, within limbic areas and striatum indicated that limbic structures possess a high sensitivity to MDMA with respect to the activation of at least one step in the apoptotic pathway.
Short-term effects of 3,4-methylen-dioxy-metamphetamine (MDMA) on 5-HT(1A) receptors in the rat hippocampus.
The results encourage the study of MDMA biochemical profiles, in the attempt to elucidate those amphetamine-induced pathways with a potential for neurotoxicity or psycho-stimulant activity, as well as indicating that the amphetamine can release 5-HT via alternative mechanisms to5-HT transporter binding, probably via membrane synaptic receptors or vesicular transporters.
Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers
Metronomic UFT and CTX with CXB in heavily pre-treated gastrointestinal patients were well tolerated and associated with interesting activity and potential predictive pharmacokinetic parameters and pharmacodynamic biomarkers have been found.
Effects of Pretreatment with N‐(2‐Chloroethyl)‐N‐Ethyl‐2‐Bromobenzylamine (DSP‐4) on Methamphetamine Pharmacokinetics and Striatal Dopamine Losses
These findings, together with the lack of a methamphetamine enhancement when DSP‐4 was injected 12 h after methamphetamine administration, suggest that in norepinephrine‐depleted animals, a more pronounced acute neuronal sensitivity to methamphetamine occurs.
Development and validation of a new GC-MS method for the detection of tramadol, O-desmethyltramadol, 6-acetylmorphine and morphine in blood, brain, liver and kidney of Wistar rats treated with the
The present method is simple, rapid and sensitive and can be used to study the pharmacokinetics, disposition and interaction of these drugs in several animal models.