Macrolactonization of peptide thioesters catalyzed by imidazole and its application in the synthesis of kahalalide B and analogues.
- Yangmei Li, M. Giulionatti, R. Houghten
- Chemistry, BiologyOrganic Letters
- 21 May 2010
The macrolactonization of peptide thioester to yield cyclic depsipeptides was developed using imidazole as a catalyst. This strategy was applied to the synthesis of kahalalide B and its analogues.