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Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans.
- Pervinder Sagoo, E. Perucha, +31 authors R. Lechler
- Biology, Medicine
- The Journal of clinical investigation
- 1 June 2010
Identifying transplant recipients in whom immunological tolerance is established or is developing would allow an individually tailored approach to their posttransplantation management. In this study,… Expand
Pretransplant Sensitization Against Angiotensin II Type 1 Receptor Is a Risk Factor for Acute Rejection and Graft Loss
- M. Giral, Y. Foucher, +13 authors D. Dragun
- American journal of transplantation : official…
- 1 October 2013
The angiotensin II type 1 receptor (AT1R) is an emerging target of functional non‐HLA antibodies (Ab). We examined the potential of determining the degree of presensitization against AT1R as a risk… Expand
Acute graft pyelonephritis and long-term kidney allograft outcome.
BACKGROUND Long-term graft function is the result of multiple parameters, including both immune and non-immune components, which have a beneficial or detrimental potential. Among these, despite its… Expand
Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype.
Several transplant patients maintain stable kidney graft function in the absence of immunosuppression. Here we compared the characteristics of their peripheral B cells to that of others who had… Expand
Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens
BACKGROUND Long-term administration of cyclosporin carries a risk of renal toxicity, and immunosuppressants are associated with an increased rate of malignant disorders. We undertook an open… Expand
Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance
- S. Brouard, E. Mansfield, +16 authors M. Sarwal
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 25 September 2007
Long-term allograft survival generally requires lifelong immunosuppression (IS). Rarely, recipients display spontaneous “operational tolerance” with stable graft function in the absence of IS. The… Expand
A clinical scoring system highly predictive of long-term kidney graft survival.
Determining early surrogate markers of long-term graft outcome is important for optimal medical management. In order to identify such markers, we used clinical information from a cross-validated… Expand
A semi-Markov model for multistate and interval-censored data with multiple terminal events. Application in renal transplantation.
- Y. Foucher, M. Giral, J. Soulillou, J. Daurès
- Computer Science, Medicine
- Statistics in medicine
- 30 December 2007
In this article, we define a semi-Markov model, allowing for interval censoring, for parametric hazard functions with a union or logical sum- or intersection-shape and for determination of initial states according to covariates. Expand
Frequency and clinical implications of development of donor-specific and non-donor-specific HLA antibodies after kidney transplantation.
- M. Hourmant, A. Cesbron-Gautier, +11 authors J. Bignon
- Journal of the American Society of Nephrology…
- 1 September 2005
The involvement of immunologic and nonimmunologic events in long-term kidney allograft failure is difficult to assess. The development of HLA antibodies after transplantation is the witness of… Expand
Highly Altered Vβ Repertoire of T Cells Infiltrating Long-Term Rejected Kidney Allografts1
- K. Gagne, S. Brouard, +7 authors J. P. Soulillou
- Medicine, Biology
- The Journal of Immunology
- 1 February 2000
Chronic rejection represents a major cause of long-term kidney graft loss. T cells that are predominant in long-term rejected kidney allografts (35 ± 10% of area infiltrate) may thus be instrumental… Expand