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Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats.
BACKGROUND & AIMS Rifaximin is used to treat patients with functional gastrointestinal disorders, but little is known about its therapeutic mechanism. We propose that rifaximin modulates the ileal… Expand
Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens
Gut anaerobes protect against pathogen invasion Intestinal infections are a common problem for young animals. One explanation is that the protective gut microbiota is not fully established in… Expand
Organochlorine insecticides, polychlorinated biphenyls, and metals in water, sediment, and green frogs from southwestern Michigan.
In an attempt to explain the etiology of frog deformities and population declines, many possible causative factors have been examined, including the input of synthetic chemicals into aquatic systems,… Expand
Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice.
BACKGROUND & AIMS Stress alters brain-gut interactions and could exacerbate intestinal disorders, including irritable bowel syndrome. Alterations in the intestinal microbiota have been associated… Expand
FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction
- S. Zhou, M. Gillilland, +6 authors C. Owyang
- The Journal of clinical investigation
- 27 November 2017
Foods high in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) exacerbate symptoms of irritable bowel syndrome (IBS); however, their mechanism of action is unknown.… Expand
Total Parenteral Nutrition–Associated Lamina Propria Inflammation in Mice Is Mediated by a MyD88-Dependent Mechanism
- E. Miyasaka, Y. Feng, +6 authors D. Teitelbaum
- Biology, Medicine
- The Journal of Immunology
- 15 June 2013
Enteral nutrient deprivation via total parenteral nutrition (TPN) administration leads to local mucosal inflammatory responses, but the underlying mechanisms are unknown. Wild-type (WT) and MyD88−/−… Expand
Ecological Succession of Bacterial Communities during Conventionalization of Germ-Free Mice
- M. Gillilland, J. Erb-Downward, +4 authors G. Huffnagle
- Biology, Medicine
- Applied and Environmental Microbiology
- 27 January 2012
ABSTRACT Little is known about the dynamics of early ecological succession during experimental conventionalization of the gastrointestinal (GI) tract; thus, we measured changes in bacterial… Expand
Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome, and immune responses in colitis.
- Y. Lee, Kohei Sugihara, M. Gillilland, S. Jon, N. Kamada, J. Moon
- Nature Materials
- 15 July 2019
While conventional approaches for inflammatory bowel diseases mainly focus on suppressing hyperactive immune responses, it remains unclear how to address disrupted intestinal barriers, dysbiosis of… Expand
Gastrointestinal Microbial Ecology with Perspectives on Health and Disease
The human microbiome is extremely diverse. New estimates of species richness, based upon culture-independent molecular techniques, put the total number of bacterial and archaeal “species” in the… Expand
Occurrence of Acanthocephalans in Largemouth Bass and Smallmouth Bass (Centrarchidae) From Gull Lake, Michigan
A total of 65 largemouth bass, Micropterus salmoides, and 27 smallmouth bass, M. dolomieu, collected in April–September 2000 and April–July 2001 from Gull Lake, Michigan, were examined for… Expand