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Pituitary Adenylate Cyclase-Activating Peptide (PACAP) in the Retinohypothalamic Tract: A Potential Daytime Regulator of the Biological Clock
A new signaling pathway by which the RHT may regulate circadian timing in the daytime as well, through a cAMP-dependent pathway, which could be blocked by a specific cAMP antagonist, Rp-cAMPS.
Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock.
- A. Hunt, W. Al-Ghoul, M. Gillette, M. Dubocovich
- BiologyAmerican journal of physiology. Cell physiology
It is concluded that melatonin mediates phase advances of the SCN circadian clock at both dusk and dawn via activation of MT(2) melatonin receptor signaling.
Resetting the Biological Clock: Mediation of Nocturnal CREB Phosphorylation via Light, Glutamate, and Nitric Oxide
- Jian M. Ding, L. E. Faiman, W. Hurst, L. Kuriashkina, M. Gillette
- BiologyThe Journal of Neuroscience
- 15 January 1997
Together, these data couple nocturnal light, Glu, NMDA receptor activation and NO signaling to CREB phosphorylation in the transduction of brief environmental light stimulation of the retina into molecular changes in the SCN resulting in phase resetting of the biological clock.
Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn.
Data demonstrate that MEL can directly modulate the circadian timing of the SCN within two windows of sensitivity corresponding to dusk and dawn; and MEL alters SCN cellular function via a pertussis toxin-sensitive G protein pathway that activates PKC.
Ca2+/cAMP Response Element-binding Protein (CREB)-dependent Activation of Per1 Is Required for Light-induced Signaling in the Suprachiasmatic Nucleus Circadian Clock*
- S. Tischkau, Jennifer W Mitchell, S. Tyan, G. F. Buchanan, M. Gillette
- BiologyThe Journal of Biological Chemistry
- 10 January 2003
Ca2+/cAMP response element-binding protein (CREB) and Per1 are integral components of the pathway transducing light-stimulated GLU neurotransmission into phase advance of the circadian clock.
Spatial light interference microscopy (SLIM)
Spatial light interference microscopy reveals the intrinsic contrast of cell structures and renders quantitative optical path-length maps across the sample, which may prove instrumental in impacting the light microscopy field at a large scale.
Requirement of Mammalian Timeless for Circadian Rhythmicity
It is suggested that mTim is required for rhythmicity and is a functional homolog of dTim on the negative-feedback arm of the mammalian molecular clockwork.
Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons
The redox oscillation could determine the excitability of SCN neurons through nontranscriptional modulation of multiple potassium (K+) channels and dynamic regulation ofSCN excitability appears to be closely tied to metabolism that engages the clockwork machinery.
A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock
These findings implicate the release of intracellular Ca2+ through ryanodine receptors in the light-induced phase delay of the circadian clock restricted to the early night.
Signaling in the suprachiasmatic nucleus: selectively responsive and integrative
Changing patterns of sensitivities demonstrate that the circadian clock controls multiple intracellular gates, which ensures that they can be opened selectively only at specific points in the circadian cycle.