• Publications
  • Influence
Pathogenesis and natural history of osteonecrosis.
TLDR
The understanding of the pathogenesis of osteonecrosis is now much better defined and skeletal scintigraphy and magnetic resonance imaging have enhanced diagnosis greatly, helping the physician determine which patients are at risk for oste onecrosis, facilitating early diagnosis and better treatment options. Expand
Risk factors and comorbidities in primary biliary cirrhosis: A controlled interview‐based study of 1032 patients
TLDR
Environmental factors, possibly including infectious agents through urinary tract infections or chemicals contained in cigarette smoke, may induce PBC in genetically susceptible individuals and exogenous estrogens may also contribute to explain the female predominance of the disease. Expand
Respiratory Syncytial Virus—A Comprehensive Review
TLDR
More research is required to define the relationships between RSV bronchiolitis, other viral induced inflammatory responses, and asthma, as well as the potential impact of co-infection and defining the natural history of RSV. Expand
Lyme disease: a rigorous review of diagnostic criteria and treatment.
Lyme disease was originally identified in Lyme, Connecticut, based upon an unusual cluster of what appeared to be patients with juvenile rheumatoid arthritis. It was subsequently identified as a newExpand
Primary biliary cirrhosis
TLDR
The most specific feature differentiating primary biliary cirrhosis from other causes of intrahepatic cholestasis is demonstration of antimitochondrial antibodies and the typical histology. Expand
Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis.
TLDR
The availability of a recombinant form of the 70 kd mitochondrial autoantigen will allow several definitive questions to be addressed in PBC, including identification of B cell epitopes, T cell recognition, and a model of PBC in mice. Expand
International consensus criteria for the diagnosis of Raynaud's phenomenon.
TLDR
A panel of 12 RP experts from 9 different institutes and four different countries were assembled for a Delphi exercise to establish new diagnostic criteria for RP, which came to an agreement that the proposed criteria were "appropriate and accurate" for use by physicians to diagnose patients with RP. Expand
Risk factors for primary biliary cirrhosis in a cohort of patients from the United States
TLDR
The significance of smoking in the multivariate models supports the findings of previous studies and raises the issue of the influence of smoking on a Th1 response. Expand
Human autoimmune diseases: a comprehensive update
TLDR
The identification of cytokines and chemokines, and their cognate receptors, has led to novel therapies that block pathological inflammatory responses within the target organ and have greatly improved the therapeutic effect in patients with autoimmune disease, particularly rheumatoid arthritis. Expand
The causes of primary biliary cirrhosis: Convenient and inconvenient truths
TLDR
It is emphasized that the potential initiator of PBC includes inter alia particular environmental xenobiotics; pathogenesis is aided and abetted by genetic weaknesses in mechanisms of immune regulation; and subsequent multilineage immunopathology impacts upon uniquely susceptible BECs to culminate clinically in the chronic autoimmune cholangiolitis of P BC. Expand
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