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Pathogenesis and natural history of osteonecrosis.
- Y. Assouline-Dayan, Christopher Chang, A. Greenspan, Y. Shoenfeld, M. Gershwin
- MedicineSeminars in arthritis and rheumatism
- 1 October 2002
The understanding of the pathogenesis of osteonecrosis is now much better defined and skeletal scintigraphy and magnetic resonance imaging have enhanced diagnosis greatly, helping the physician determine which patients are at risk for oste onecrosis, facilitating early diagnosis and better treatment options.
Risk factors and comorbidities in primary biliary cirrhosis: A controlled interview‐based study of 1032 patients
Environmental factors, possibly including infectious agents through urinary tract infections or chemicals contained in cigarette smoke, may induce PBC in genetically susceptible individuals and exogenous estrogens may also contribute to explain the female predominance of the disease.
Human autoimmune diseases: a comprehensive update
The identification of cytokines and chemokines, and their cognate receptors, has led to novel therapies that block pathological inflammatory responses within the target organ and have greatly improved the therapeutic effect in patients with autoimmune disease, particularly rheumatoid arthritis.
Respiratory Syncytial Virus—A Comprehensive Review
- A. Borchers, Christopher Chang, M. Gershwin, L. Gershwin
- Biology, MedicineClinical Reviews in Allergy & Immunology
- 12 April 2013
More research is required to define the relationships between RSV bronchiolitis, other viral induced inflammatory responses, and asthma, as well as the potential impact of co-infection and defining the natural history of RSV.
Primary biliary cirrhosis
The most specific feature differentiating primary biliary cirrhosis from other causes of intrahepatic cholestasis is demonstration of antimitochondrial antibodies and the typical histology.
Lyme disease: a rigorous review of diagnostic criteria and treatment.
International consensus criteria for the diagnosis of Raynaud's phenomenon.
Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis.
The availability of a recombinant form of the 70 kd mitochondrial autoantigen will allow several definitive questions to be addressed in PBC, including identification of B cell epitopes, T cell recognition, and a model of PBC in mice.
The causes of primary biliary cirrhosis: Convenient and inconvenient truths
It is emphasized that the potential initiator of PBC includes inter alia particular environmental xenobiotics; pathogenesis is aided and abetted by genetic weaknesses in mechanisms of immune regulation; and subsequent multilineage immunopathology impacts upon uniquely susceptible BECs to culminate clinically in the chronic autoimmune cholangiolitis of P BC.