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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
TLDR
A meta-analysis of six ulcerative colitis genome-wide association study datasets found many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. Expand
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
TLDR
A genome-wide association study with 440,794 SNPs genotyped in 1,167 individuals with UC and 777 healthy controls strongly suggests that defective IL10 function is central to the pathogenesis of the UC subtype of IBD. Expand
Effect of Peroxisome Proliferators on Leydig Cell Peripheral-Type Benzodiazepine Receptor Gene Expression, Hormone-Stimulated Cholesterol Transport, and Steroidogenesis: Role of the Peroxisome
TLDR
The results suggest that the antiandrogenic effect of PPs is mediated by a PPARdependent inhibition of Leydig cell PBR gene expression. Expand
Expression of microRNAs, miR‐21, miR‐31, miR‐122, miR‐145, miR‐146a, miR‐200c, miR‐221, miR‐222, and miR‐223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its
TLDR
Evaluation of the expression of certain microRNAs in patients with hepatocellular carcinoma and intrahepatic cholangiocarcinoma found them to be over‐expressed, whereas in ICC tissues no correlation with clinicopathological features was found. Expand
Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer.
TLDR
Apart from shedding light on the mechanisms of malignancy initiation and progression, SNPs may improve appropriate screening for sub-populations at risk. Expand
Detection of Mycobacterium avium subsp. paratuberculosis in Retail Cheeses from Greece and the Czech Republic
ABSTRACT We investigated the presence of Mycobacterium avium subsp. paratuberculosis in retail cheeses from Greece and the Czech Republic. We found that 31.7% and 3.6% of our samples reacted positiveExpand
Vascular endothelial growth factor polymorphisms in gastric cancer development, prognosis, and survival
Angiogenesis plays an important role in growth, progression, and metastasis of tumors. Vascular endothelial growth factor (VEGF) overexpression has been associated with advanced stage and poorExpand
Survivin -31G/C promoter polymorphism and sporadic colorectal cancer
TLDR
The -31CC genotype of survivin promoter is associated with CRC and may be a risk factor for CRC. Expand
Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population.
TLDR
It is indicated that co-existence of a mutation in either the TLR4 or CD14 gene, and in NOD2/CARD15 is associated with an increased susceptibility to developing CD compared to UC, and to developing either CD or UC compared to healthy individuals. Expand
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer
TLDR
This study identifies new loci associated with pancreatic cancer risk in North America, Central Europe and Australia and replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1) and 13q12.4 (NR5A2), a region with previous suggestive evidence in Han Chinese. Expand
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