• Publications
  • Influence
Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.
Translocator protein (18kDa) is proposed as a new name, regardless of the subcellular localization of the protein, to represent more accurately its sub cellular role (or roles) and putative tissue-specific function (or functions). Expand
Enigma of the peripheral benzodiazepine receptor.
Benzodiazepines (BZs)2 are used clinically as muscle relaxants, anticonvulsants, anxiolytics, and sedative-hypnotics. These effects are mediated primarily via the central BZ receptors (CBRs) locatedExpand
Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response.
It is suggested that the involvement of TSPO and its ligands in such seemingly disparate biological functions as immunological responses, apoptosis, and steroidogenesis may have a common denominator in the multi-dimensional role of T SPO in the host-defense response to disease and injury. Expand
The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development.
Peripheral-type benzodiazepine receptors in the cardiovascular system may represent a new target for drug development because PBRs in blood cells appear to play roles in several aspects of the immune response, such as phagocytosis and the secretion of interleukin-2, interleukain-3, and immunoglobulin A. Expand
VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis
Understanding is provided regarding the mechanisms whereby VDAC and TSPO may serve as targets to modulate apoptotic rates, which has implications for drug design to treat diseases such as neurodegeneration and cancer. Expand
Salivary analysis of oral cancer biomarkers
Cancer-related changes in salivary tumour markers may be used as a diagnostic tool for diagnosis, prognosis and post-operative monitoring, as all alterations correlated with each other may belong to a single carcinogenetic network. Expand
Acute and Repeated Swim Stress Effects on Peripheral Benzodiazepine Receptors in the Rat Hippocampus, Adrenal, and Kidney
The acute rather than the repeated stress led to robust alterations in PBRdensity, and the largest reduction in hippocampal and adrenal gland PBR density was found one hour after acute stress. Expand
The role of 18 kDa mitochondrial translocator protein (TSPO) in programmed cell death, and effects of steroids on TSPO expression.
The notion that enhanced expression and/or activation of the TSPO leads to cell death, and the potential of steroids to regulate T SPO expression and activation are focused on. Expand
The effect of oxygenation level on cerebral post‐traumatic apoptotsis is modulated by the 18‐kDa translocator protein (also known as peripheral‐type benzodiazepine receptor) in a rat model of
The present findings suggest that the protective effect of hyperoxia may be due to a negative regulation of the proapoptotic function of mitochondrial TSPO, including conservation of the mitochondrial membrane potential. Expand
Binding of [3H]Ro 5–4864 and [3H]PK 11195 to Cerebral Cortex and Peripheral Tissues of Various Species: Species Differences and Heterogeneity in Peripheral Benzodiazepine Binding Sites
Abstract: The binding of [3H]PK 11195 and [3H]Ro 5–4864 to membrane preparations from cerebral cortex and peripheral tissues of various species was studied. [3H]PK 11195 (0.05–10 nM) bound with highExpand