M. Gardner

Publications83
h-index39
Citations14,029
Highly Influential Citations610
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Genome sequence of the human malaria parasite Plasmodium falciparum
TLDR
The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria.
View on Nature
TriTrypDB: a functional genomic resource for the Trypanosomatidae
TLDR
TriTrypDB is an integrated database providing access to genome-scale datasets for kinetoplastid parasites, and supporting a variety of complex queries driven by research and development needs, utilizing a sophisticated search strategy system.
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The Genome Sequence of the Malaria Mosquito Anopheles gambiae
TLDR
Analysis of the PEST strain of A. gambiae revealed strong evidence for about 14,000 protein-encoding transcripts, and prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted.
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A proteomic view of the Plasmodium falciparum life cycle
TLDR
A high-throughput proteomics approach was applied to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite.
View on Nature
Comparative genomics of the neglected human malaria parasite Plasmodium vivax
TLDR
The synteny and isochore structure of P. vivax chromosomes are described, and it is shown that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously.
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Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
TLDR
This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.
View on Nature
Genome Sequence of Theileria parva, a Bovine Pathogen That Transforms Lymphocytes
TLDR
The genome sequence of Theileria parva is reported, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand.
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Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives.
TLDR
The results suggest that Coccidioides species are not soil saprophytes, but that they have evolved to remain associated with their dead animal hosts in soil, and that C Occidioide metabolism genes, membrane-related proteins, and putatively antigenic compounds have evolved in response to interaction with an animal host.
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Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.
TLDR
The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible and a family of surface proteins, rifins, that may play a role in antigenic variation was identified.
View on PubMed
Theileria: intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks
TLDR
Key parameters in T. parva population dynamics are the relative importance of asymptomatic carrier cattle and animals undergoing severe disease, in transmission of the parasite to ticks, and the extent of transmission by nymphs as compared to adult ticks.
View on Cambridge Press
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