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Dopamine transporter imaging does not predict the number of nigral neurons in Parkinson disease
TLDR
This cohort study demonstrates that postmortem SNc neuron counts are not associated with striatal DAT binding in PD, fitting with the theory that there is no correlation between the number of substantia nigra neurons and striatal dopamine after a certain level of damage has occurred.
Comparison of Somatostatin Receptor 2-Targeting PET Tracers in the Detection of Mouse Atherosclerotic Plaques
TLDR
Results demonstrate superior applicability for [68Ga]DOTANOC and [68 Ga]DotATATE in the detection of atherosclerotic plaques compared to [18F]FDR-NOC in in vivo PET/CT imaging.
Serum levels of GFAP and EGFR in primary and recurrent high-grade gliomas: correlation to tumor volume, molecular markers, and progression-free survival
TLDR
Correlation with tumor burden in recurrent HGG implicates the potential of serum GFAP for detection of tumor recurrence and suggests that circulating EGFR is not derived from glioma cells and cannot be used as a marker for EGFR status in the tumor.
FHOD1, a Formin Upregulated in Epithelial-Mesenchymal Transition, Participates in Cancer Cell Migration and Invasion
TLDR
It is shown that FHOD1 upregulation occurs during cancer cell EMT in vivo, which indicates that FhOD1 may contribute to tumour progression, and cytoskeletal changes in EMT are participated in.
Somatostatin receptor subtype 2 in high-grade gliomas: PET/CT with 68Ga-DOTA-peptides, correlation to prognostic markers, and implications for targeted radiotherapy
TLDR
In HGGs, uptake of 68Ga-DOTA-peptides is associated with disrupted BBB and cannot be predicted by SSTR2 immunohistochemistry, and PET/CT shows limited value to detect H GGs suitable for PRRT.
Normal dopamine transporter SPECT in neuropathologically confirmed corticobasal degeneration
TLDR
The role of dopamine transporter imaging in the diagnosis of corticobasal syndrome (CBS) is unclear and high variability in dopamine transporter binding is shown, and four of the clinically probable CBD patients had normal scans.
Characterization of Leukocyte Formin FMNL1 Expression in Human Tissues
TLDR
This work characterize, using bioinformatics tools and a validated antibody, the expression pattern of FMNL1 in human tissues and study its subcellular distribution, indicating that FMNL 1 expression is not restricted to hematopoietic tissues and that neoexpression ofFMNL1 can be seen in epithelial cancer.
Characterization of Diaphanous-related formin FMNL2 in human tissues
TLDR
Immunohistochemical analysis of 26 different human tissues showed that FMNL2 is widely expressed, in agreement with the mRNA profile, and the expression is especially strong in gastrointestinal and mammary epithelia, lymphatic tissues, placenta, and in the reproductive tract.
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