• Publications
  • Influence
A pivotal role for galectin-1 in fetomaternal tolerance
A successful pregnancy requires synchronized adaptation of maternal immune-endocrine mechanisms to the fetus. Here we show that galectin-1 (Gal-1), an immunoregulatory glycan-binding protein, has aExpand
  • 393
  • 7
  • PDF
Articular chondrocytes express connexin 43 hemichannels and P2 receptors – a putative mechanoreceptor complex involving the primary cilium?
Mechanical loading is essential for the health and homeostasis of articular cartilage, although the fundamental mechanotransduction pathways are unclear. Previous studies have demonstrated thatExpand
  • 120
  • 7
  • PDF
Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway
  • M. Garcia, M. Knight
  • Chemistry, Medicine
  • Journal of orthopaedic research : official…
  • 4 November 2009
The process of chondrocyte mechanotransduction is poorly understood. However, recent studies suggest the involvement of a purinergic calcium signaling pathway although the mechanism of ATP releaseExpand
  • 78
  • 4
Overexpression of SPARC obliterates the in vivo tumorigenicity of human hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer‐related death worldwide. Current treatments are extremely disappointing. SPARC (Secreted protein,Expand
  • 40
  • 3
Hydrogen Peroxide Induces Apoptotic-Like Cell Death in Coelomocytes of Themiste petricola (Sipuncula)
Apoptosis is an active form of cell death that plays a critical role in physiological and pathological conditions of multicellular organisms. These conditions include development, organogenesis, andExpand
  • 15
  • 2
SPARC downregulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-β1 and PDGF.
Liver fibrosis is an active process that involves changes in cell-cell and cell-extracellular matrix (ECM) interaction. Secreted protein, acidic and rich in cysteine (SPARC) is an ECM protein withExpand
  • 28
  • 1
  • PDF
Disruption of mitochondrial membrane potential during apoptosis induced by PSC 833 and CsA in multidrug-resistant lymphoid leukemia.
Previous findings from our laboratory demonstrated that when used at low concentration (0.1 microg ml(-1)), CsA as well as its analog PSC 833 were able to revert the MDR phenotype, while at highExpand
  • 34
  • 1
A Novel Synergistic Combination of Cyclophosphamide and Gene Transfer of Interleukin-12 Eradicates Colorectal Carcinoma in Mice
Purpose: Interleukin-12 (IL-12) is an immunostimulatory cytokine with potent antitumor effects in several animal models. However, serious toxicity has been associated with its systemic application inExpand
  • 37
  • PDF
Multidrug resistance modulators PSC 833 and CsA show differential capacity to induce apoptosis in lymphoid leukemia cell lines independently of their MDR phenotype.
Among the mechanisms that induce multidrug resistance (MDR), one of those most frequent is over-expression of a phosphoglycoprotein (Pgp) encoded in the mouse by the mdr-1 and mdr-3 genes. We haveExpand
  • 19