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tRNA-Derived Small Non-Coding RNAs as Novel Epigenetic Molecules Regulating Adipogenesis
Results imply that tRFGluTTC may act as a novel epigenetic molecule regulating adipogenesis and could provide a new strategy for the intervention treatment of obesity.
MicroRNA-125a-5p Affects Adipocytes Proliferation, Differentiation and Fatty Acid Composition of Porcine Intramuscular Fat
- Jingjing Du, Yan Xu, +10 authors Li Zhu
- Chemistry, MedicineInternational journal of molecular sciences
- 1 February 2018
It is found that the expression of miR-125a-5p is dynamically regulated during porcine intramuscular preadipocytes differentiation and that its expression levels in different porcines muscle tissues were negatively involved with IMF content.
MicroRNA-204-5p regulates 3T3-L1 preadipocyte proliferation, apoptosis and differentiation.
Findings showed that miR-204-5p inhibits proliferation and induces apoptosis of preadipocytes by regulating Bcl-2, but also promotes adipocyte differentiation by targeting KLF3, a negative regulator of lipogenesis.
Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet
Dietary betaine supplementation limits HFD-induced obesity and improves insulin resistance, and is associated with increasing polyunsaturated fatty acids (PUFA), fatty acid oxidation, and the inhibition of fatty acid synthesis in muscle.
MicroRNA-200b regulates preadipocyte proliferation and differentiation by targeting KLF4.
- Linyuan Shen, M. Gan, +4 authors Li Zhu
- Medicine, ChemistryBiomedicine & pharmacotherapy = Biomedecine…
- 1 July 2018
Overexpression of miR-200b reduced lipid accumulation and triglyceride content in adipocytes, and accompanied by a marked decrease in the expression of adipocyte-specific genes involved in fatty acid synthesis, indicate that miR200b may be involved in adipogenesis and could be a target for therapeutic intervention in obesity and metabolic syndrome.
A Novel Class of tRNA-Derived Small Non-Coding RNAs Respond to Myocardial Hypertrophy and Contribute to Intergenerational Inheritance
Results demonstrated that tRFs are involved in regulating the response of myocardial hypertrophy, and might serve as novel epigenetic factors that contribute to the intergenerational inheritance of cardiachypertrophy.
Genistein reverses isoproterenol-induced cardiac hypertrophy by regulating miR-451/TIMP2.
- M. Gan, Ting Zheng, +8 authors Li Zhu
- MedicineBiomedicine & pharmacotherapy = Biomedecine…
- 1 April 2019
It is suggested that miR-451 may play a significant role in the genistein-assisted amelioration of isoproterenol-induced cardiac hypertrophy both in vitro and in vivo.
miR-152 regulates the proliferation and differentiation of C2C12 myoblasts by targeting E2F3
- M. Gan, Jingjing Du, +10 authors Li Zhu
- Chemistry, MedicineIn Vitro Cellular & Developmental Biology…
- 5 March 2018
It is found that the expression of miR-152 was gradually down-regulated during myoblast proliferation, but gradually up- regulated during the differentiation of myoblasts, and showed that mi R-152 inhibited proliferation and promoted myOBlast differentiation by targeting E2F3.
Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles
- Linyuan Shen, M. Gan, +11 authors Li Zhu
- Biology, MedicineInternational journal of molecular sciences
- 1 June 2019
A mass of candidate lncRNAs and circRNAs involved in muscle physiological functions are revealed, which may improve understanding of muscle metabolism and development from an epigenetic perspective.
High Altitude Adaptability and Meat Quality in Tibetan Pigs: A Reference for Local Pork Processing and Genetic Improvement
- M. Gan, Linyuan Shen, +9 authors Li Zhu
- Medicine, BiologyAnimals : an open access journal from MDPI
- 1 December 2019
This study explains the high-altitude adaptive evolution and the formation of meat quality differences in different altitude pigs from various angles and provides a reference for local pork food processing and genetic improvement of local pigs.