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Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model
Alemtuzumab is a humanized monoclonal antibody against CD52, an antigen found on the surface of normal and malignant lymphocytes. It is approved for the treatment of B‐cell chronic lymphocyticExpand
Efficient retrovirus transduction of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor
: Cytokine-mobilized peripheral blood cells have been shown to participate in hematopoietic recovery after bone marrow (BM) transplantation, and are proposed to be useful targets forExpand
Efficient retrovirus transduction of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor.
Cytokine-mobilized peripheral blood cells have been shown to participate in hematopoietic recovery after bone marrow (BM) transplantation, and are proposed to be useful targets forExpand
Enhancement of the anti-tumor activity of therapeutic monoclonal antibodies by CXCR4 antagonists
Abstract The interaction between CXCR4 on the surface of tumor cells and CXCL12 in the stroma is believed to contribute to tumor cell survival and protection against drug treatment. Inhibition ofExpand
Treatment with the CXCR4 Antagonist AMD3100 Enhances Antibody Mediated Killing in Disseminated Lymphoma Models.
Abstract 2717 Poster Board II-693 Interactions between chemokines and their receptors play an important role in cancer biology and have been shown to influence several processes such as tumor growthExpand
Liver bacterial dysbiosis occurs in SIV-infected macaques and persists during antiretroviral therapy
Bridget S Fisher Seattle Children's Research Institute Katherine A Fancher Seattle Children's Research Institute Andrew T Gustin University of Washington Cole Fisher Seattle Children's ResearchExpand
Abstract #LB-160: CXCR4 antagonist as a sensitizing agent for anti-tumor therapies in disseminated lymphoma models
AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO CXCR4 is a chemokine receptor frequently over-expressed on hematological cancers and solid tumors. CXCR4 plays an important role in cancerExpand
Abstract 4460: Mechanism of action of small molecule CXCR4 antagonists in human B-lymphoma cell lines
CXCR4 is a chemokine receptor frequently over-expressed on hematological cancers and solid tumors. CXCR4 and its ligand SDF1α (stromal derived factor-1α or CXCL12) play an important role in cancerExpand