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Projecting individualized probabilities of developing breast cancer for white females who are being examined annually.
To assist in medical counseling, we present a method to estimate the chance that a woman with given age and risk factors will develop breast cancer over a specified interval. The risk factors usedExpand
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Excess deaths associated with underweight, overweight, and obesity.
CONTEXT As the prevalence of obesity increases in the United States, concern over the association of body weight with excess mortality has also increased. OBJECTIVE To estimate deaths associatedExpand
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Cause-specific excess deaths associated with underweight, overweight, and obesity.
CONTEXT The association of body mass index (BMI) with cause-specific mortality has not been reported for the US population. OBJECTIVE To estimate cause-specific excess deaths associated withExpand
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A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 SNPs. We report a combinedExpand
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A Prospective Study of Red and Processed Meat Intake in Relation to Cancer Risk
Background Red meat and processed meat have been associated with carcinogenesis at several anatomic sites, but no prospective study has examined meat intake in relation to a range of malignancies. WeExpand
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Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
We report a set of tools to estimate the number of susceptibility loci and the distribution of their effect sizes for a trait on the basis of discoveries from existing genome-wide association studiesExpand
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Validation studies for models projecting the risk of invasive and total breast cancer incidence.
BACKGROUND In 1989, Gail and colleagues developed a model for estimating the risk of breast cancer in women participating in a program of annual mammographic screening (designated herein as model 1).Expand
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Cancer burden in the HIV-infected population in the United States.
BACKGROUND Effective antiretroviral therapy has reduced the risk of AIDS and dramatically prolonged the survival of HIV-infected people in the United States. Consequently, an increasing number ofExpand
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Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer.
BACKGROUND In response to findings from the Breast Cancer Prevention Trial that tamoxifen treatment produced a 49% reduction in the risk of invasive breast cancer in a population of women at elevatedExpand
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Biased estimates of treatment effect in randomized experiments with nonlinear regressions and omitted covariates
SUMMARY Certain important nonlinear regression models lead to biased estimates of treatment effect, even in randomized experiments, if needed covariates are omitted. The asymptotic bias is determinedExpand
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