M. G. Ponnapalli

Publications20
h-index6
Citations90
Highly Influential Citations1
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Biotransformation of Artemisinin to 14-Hydroxydeoxyartemisinin: C-14 Hydroxylation by Aspergillus flavus.
TLDR
This is the first report of hydroxylation of a secondary methyl of artemisinin at C-14 by the fungus A. flavus, which is synthetically not accessible.
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Unusual isomeric corniculatolides from mangrove, Aegiceras corniculatum.
TLDR
Four new isomeric macrolides of combretastatin D-2 congeners named isocorniculatolide A, 11-O-methylisocorno-methylcornicULatolides A, and 12-hydroxy-11- O-methyl cornicul atolide B are isolated from the CHCl(3) extract of the bark of Aegiceras corniculatum.
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Unusual ent-isopimarane-type diterpenoids from the wood of Excoecaria agallocha
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α-Glucosidase Inhibitory Isomeric Corniculatolides from the Stems of the Indian Mangrove Plant, Xylocarpus granatum.
TLDR
Three new isomeric corniculatolides with an unusual caffrane and isocorniculane framework, and five known metabolites were isolated from the chloroform extract of the stems of Xylocarpus granatum, showing no effect on the mammalian cancer cell lines MIAPaCa-2, DU145, MCF-7, and HTC-116.
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Two New Cerioptins (A-B) from the Mangrove Ceriops tagal
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Self gelating isoracemosol A, new racemosaceramide A, and racemosol E from Barringtonia racemosa
TLDR
Phytochemical investigation into the CHCl3 extract of the fruits of Barringtonia racemosa resulted in the isolation of two new metabolites along with isoracemosol A and betulinic acid as known metabolites, which leads to the unexpected agglomerated porous-like morphology.
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Ipomeolides A and B, Resin Glycosides from Ipomoea pes-caprae and Combination Therapy of Ipomeolide A with Doxorubicin.
TLDR
A sublethal concentration of compound 1 when used in combination with 1 μM doxorubicin, an anticancer agent, significantly enhanced cytotoxicity to tumor cells, suggesting combined synergistic potency against leukemia cells and the absence of effects on epithelial cells may be beneficial for chemotherapy with minimal side effects to treat CML (chronic myeloid leukemia) malignancies.
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α-Glucosidase inhibitory monoacylated polyhydroxytriterpenoids from the fruits of Barringtonia racemosa
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Epimeric Excolides from the Stems of Excoecaria agallocha and Structural Revision of Rhizophorin A.
Excolides A-B (1-4) represent the first examples of a new class of secolabdanoids with an unprecedented framework, which were isolated from the stems of Excoecaria agallocha. Their structures were…
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Betulinic acid derivatives: a new class of α-glucosidase inhibitors and LPS-stimulated nitric oxide production inhibition on mouse macrophage RAW 264.7 cells
TLDR
Twenty-one new rationally designed analogues of 1 with modifications at C-28 were synthesized for their evaluation of inhibitory effects on α-glucosidase and LPS-stimulated nitric oxide production in mouse macrophage RAW 2647 cells and exhibited enhanced inhibitory activity on NO-production.
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