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Active site substitutions delineate distinct classes of eubacterial flap endonuclease
FENs (flap endonucleases) play essential roles in DNA replication, pivotally in the resolution of Okazaki fragments. In eubacteria, DNA PolI (polymerase I) contains a flap processing domain, the… Expand
Molecular interactions of Escherichia coli ExoIX and identification of its associated 3′–5′ exonuclease activity
The flap endonucleases (FENs) participate in a wide range of processes involving the structure-specific cleavage of branched nucleic acids. They are also able to hydrolyse DNA and RNA substrates from… Expand
Development of a design strategy for an established semi-technical product. A case study of a safety harness for tree workers
Abstract This paper briefly reviews a range of well-known design methods and describes how they can be strategically combined in groups to assist the re-design of a safety harness for tree workers.… Expand