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Cytokinesis in animal cells.
TLDR
The cytoskeletal structures, factors, and signaling pathways that orchestrate this robust and yet highly dynamic process in animal cells, known as cytokinesis, are described. Expand
The Class I PITP Giotto Is Required for Drosophila Cytokinesis
TLDR
It is found that giotto (gio), a Drosophila gene that encodes a class I PITP, serves an essential function required for both mitotic and meiotic cytokinesis, and it is proposed that Gio mediates transfer of lipid monomers from the ER to the equatorial membrane, causing a specific local enrichment in phosphatidylinositol. Expand
Drosophila SPD-2 Is an Essential Centriole Component Required for PCM Recruitment and Astral-Microtubule Nucleation
TLDR
It is shown that null mutations carrying early stop codons in the DSpd-2 coding sequence suppress astral microtubule (MT) nucleation in both neuroblasts (NBs) and spermatocytes and indicates that DSpD-2 functions in a very early step of the PCM recruitment pathway. Expand
The Drosophila Cog5 homologue is required for cytokinesis, cell elongation, and assembly of specialized Golgi architecture during spermatogenesis.
TLDR
It is shown that function of the gene four way stop (fws), which encodes the Drosophila Cog5 homologue, is necessary for dramatic changes in cellular and subcellular morphology during spermatogenesis and proposed that Fws may directly or indirectly facilitate efficient vesicle traffic through the Golgi to support rapid and extensive increases in cell surface area. Expand
Spindle Self-organization and Cytokinesis During Male Meiosis in asterless Mutants of Drosophila melanogaster
TLDR
These findings challenge the classical view on central spindle assembly, arguing for a self-organization of this structure from either preexisting or newly formed microtubules, and strongly suggest that the asters are not required for signaling cytokinesis. Expand
The role of centrosomes and astral microtubules during asymmetric division of Drosophila neuroblasts.
TLDR
The results indicate that the cleavage plane is dictated by the positioning of the central spindle midzone within the cell, and suggest a model on how thecentral spindle attains an asymmetric position during neuroblast mitosis. Expand
Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis.
TLDR
Male meiosis in mutants of the chickadee (chic) locus, a Drosophila melanogaster gene that encodes profilin, a low molecular weight actin-binding protein that modulates F-actin polymerization indicates that proper actin assembly is necessary for centrosome separation and migration. Expand
Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males.
TLDR
This work shows that Rab11 accumulates at the cleavage furrow of Drosophila spermatocytes and that it is essential for cytokinesis, and proposes that Gio and Fwd mediate Rab11 recruitment at the Cleavage furrows and that Rab 11 facilitates targeted membrane delivery to the advancing furrow. Expand
TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila
TLDR
It is suggested that Bru cooperates with Rab11 and PI4Kβ to regulate the efficiency of membrane addition to the cleavage furrow, thus promoting cytokinesis in Drosophila male meiotic cells. Expand
Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis
TLDR
It is shown that Drosophila secondary spermatocytes can assemble morphologically normal spindles in the absence of chromosomes, suggesting that the association of Aurora B with chromosomes is not a prerequisite for its accumulation at the central spindle, or for its function during cytokinesis. Expand
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