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SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues
TLDR
Results reveal that the relative level of TIF2/SRC-1 can modulate energy metabolism, which may contribute to weight gain on a high-fat diet.
The Function of TIF2/GRIP1 in Mouse Reproduction Is Distinct from Those of SRC-1 and p/CIP
TLDR
It is concluded that TIF2 plays a critical role in mouse reproductive functions, whereas previous reports have not revealed serious fertility impairment in SRC-1+/− or p/CIP−/− mutants.
Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
TLDR
The results reveal the rational basis of RAR isotype selectivity, explain the existence of class I and II retinoids, and provide a structural concept of ligand-mediated antagonism.
Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial.
TLDR
Adjunctive bosentan was well tolerated, but did not improve oxygenation or other outcomes in patients with PPHN, and this effect may be related to delayed absorption ofbosentan on treatment initiation in critically ill neonates or to more severe illness of the neonates who received bosENTan.
Steroid Receptor Coactivator 2 Is Critical for Progesterone-Dependent Uterine Function and Mammary Morphogenesis in the Mouse
TLDR
It is concluded that SRC-2 is appropriated by PR in a subset of transcriptional cascades obligate for normal uterine and mammary morphogenesis and function.
Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction.
TLDR
It is demonstrated that, through analyses of SRC-1/TIF2 compound mutant mice, S RC-1 can partially compensate for the effects of a loss of TIF2 on mouse survival and growth, whereas SRC -1 and Tif2 are dispensable for primary organogenesis.
Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency.
TLDR
This work demonstrates gene dosage effect in nuclear coactivators manifesting as haploinsufficiency and functional redundancy of SRC-1 and TIF-2.
Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF‐2 deficient mice
TLDR
Hyperactivity of the hypothalamo‐pituitary unit is ascribed to insidious adrenal insufficiency and impaired glucocorticoid feedback, and the view that TIF‐2 deletion disrupts adrenocortical development and steroid biosynthesis is strengthened.
Minimal systemic and high faecal exposure to cadazolid in patients with severe Clostridium difficile infection.
TLDR
Cadazolid systemic exposure following a single 3000 mg oral dose was very low, with a peak plasma concentration of 2.64 ng/mL and an area under the concentration-time curve (AUC(0-144) of 125 ng×h/mL, whereas total systemic exposure was ca.
Pharmacokinetic interactions between the orexin receptor antagonist almorexant and the CYP3A4 inhibitors ketoconazole and diltiazem.
TLDR
The present results indicate that dose adaptation must be considered when almorexant would be coadministered with inhibitors of CYP3A4, and that higher almorezant exposure was associated with an increased incidence of typical almoreXant-related adverse events such as fatigue and somnolence.
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