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Heavy Grignard reagents: challenges and possibilities of aryl alkaline earth metal compounds.
TLDR
First results from quantum chemical calculations on diaryl dicalcium(I) suggest a long Ca-- Ca bond with a considerable Ca--Ca bond dissociation energy.
Heteroleptic Phenylcalcium Derivatives via Metathesis Reactions of PhCa(thf)4I with Potassium Compounds
The metathesis reactions of (thf)4Ca(Ph)I with the corresponding potassium compounds KR yield the heteroleptic arylcalcium derivatives (thf)3Ca(Ph)[N(SiMe3)2] (1) and (thf)4Ca(Ph)PPh2 (2), due to the
Synthesis and Spectroscopic Properties of Arylcalcium Halides
The direct synthesis of activated calcium with aryl halides in tetrahydrofuran (THF) gave the following compounds of the type RCaX in fair to good yields: [Mescal(THF) 4 ] (1), [(p-tolyl)CaI(THF) 4 ]
Enantioselective syntheses of 2,5-disubstituted pyrrolidines based on iridium-catalyzed allylic aminations--total syntheses of alkaloids from amphibian skins.
A broadly applicable route to trans-2,5-disubstituted pyrrolidines has been developed. Key steps are an asymmetric iridium-catalyzed allylic amination, a Suzuki-Miyaura coupling, and an
Enantio- and regioselective iridium-catalyzed allylic hydroxylation.
The first enantioselective allylic hydroxylation to prepare branched allylic alcohols directly is described. Bicarbonate was used as nucleophile in conjunction with new single component Ir-catalysts,
Aryl calcium compounds: syntheses, structures, physical properties, and chemical behavior.
TLDR
A decrease of reactivity and an enhanced stability at higher temperatures can be achieved by shielding of the calcium atom by increasing the coordination number of the metal center or by substitution of the iodide anion by bulky groups.
Enantioselective syntheses of the alkaloids cis-195A (pumiliotoxin C) and trans-195A based on multiple applications of asymmetric catalysis.
Short enantio- and diastereoselective syntheses of the decahydroquinoline alkaloids cis- (pumiliotoxin C) and trans-195A are presented. Key steps are an enantioselective iridium-catalyzed allylic
Enantioselective iridium-catalyzed allylic substitutions with hydroxamic acid derivatives as N-nucleophiles.
TLDR
Enantioselective Ir-catalyzed allylic aminations with hydroxamic acid derivatives are described, which transformed into piperidine derivatives suited as precursors for aza-sugars.
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