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Control of mitochondrial morphology by a human mitofusin.
Although changes in mitochondrial size and arrangement accompany both cellular differentiation and human disease, the mechanisms that mediate mitochondrial fusion, fission and morphogenesis inExpand
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Orientation of Asymmetric Stem Cell Division by the APC Tumor Suppressor and Centrosome
Stem cell self-renewal can be specified by local signals from the surrounding microenvironment, or niche. However, the relation between the niche and the mechanisms that ensure the correct balanceExpand
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Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue
Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cellsExpand
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Developmentally Regulated Mitochondrial Fusion Mediated by a Conserved, Novel, Predicted GTPase
The Drosophila melanogaster fuzzy onions (fzo) gene encodes the first known protein mediator of mitochondrial fusion. During Drosophila spermatogenesis, mitochondria in early postmeiotic spermatidsExpand
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Mitochondrial Fusion in Yeast Requires the Transmembrane GTPase Fzo1p
Membrane fusion is required to establish the morphology and cellular distribution of the mitochondrial compartment. In Drosophila, mutations in the fuzzy onions (fzo) GTPase block a developmentallyExpand
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Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells
Mitochondrial fusion may regulate mitochondrial morphogenesis and underlie complementation between mitochondrial genomes in mammalian cells. The nuclear encoded mitochondrial proteins Mfn1 and Mfn2Expand
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Monoclonal antibodies specific for an acetylated form of alpha-tubulin recognize the antigen in cilia and flagella from a variety of organisms
Seven monoclonal antibodies raised against tubulin from the axonemes of sea urchin sperm flagella recognize an acetylated form of alpha-tubulin present in the axoneme of a variety of organisms. TheExpand
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Somatic support cells restrict germline stem cell self-renewal and promote differentiation
Stem cells maintain populations of highly differentiated, short-lived cell-types, including blood, skin and sperm, throughout adult life. Understanding the mechanisms that regulate stem cellExpand
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Assembly of ring canals in the male germ line from structural components of the contractile ring.
Stable intercellular bridges called ring canals form following incomplete cytokinesis, and interconnect mitotically or meiotically related germ cells. We show that ring canals in DrosophilaExpand
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Male and Female Drosophila Germline Stem Cells: Two Versions of Immortality
Drosophila male and female germline stem cells (GSCs) are sustained by niches and regulatory pathways whose common principles serve as models for understanding mammalian stem cells. Despite strikingExpand
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