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Control of mitochondrial morphology by a human mitofusin.
TLDR
Two human genes encoding potential mediators of mitochondrial fusion are identified and it is suggested that the Mfn2 GTPase regulates or mediates mitochondrial fusion and that mitofusins and dynamin related GTPases play opposing roles in mitochondria fusion and fission in mammals, as in yeast. Expand
Orientation of Asymmetric Stem Cell Division by the APC Tumor Suppressor and Centrosome
TLDR
It is shown that dividing Drosophila male germline stem cells use intracellular mechanisms involving centrosome function and cortically localized Adenomatous Polyposis Coli tumor suppressor protein to orient mitotic spindles perpendicular to the niche, ensuring a reliably asymmetric outcome. Expand
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis
TLDR
It is suggested that Bax participates in apoptotic fragmentation of mitochondria, a proapoptotic member of the Bcl-2 family that translocates to discrete foci on mitochondria during the initial stages of apoptosis, which subsequently become mitochondrial scission sites. Expand
Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue
TLDR
It is demonstrated that the apical hub cells in the Drosophila testis act as a cellular niche that supports stem cell self-renewal and continual maintenance of the germ line stem cell population. Expand
Developmentally Regulated Mitochondrial Fusion Mediated by a Conserved, Novel, Predicted GTPase
TLDR
The Drosophila melanogaster fuzzy onions fzo gene encodes the first known protein mediator of mitochondrial fusion, a large, novel, predicted transmembrane GTPase that becomes detectable on spermatid mitochondria late in meiosis II, just prior to fusion, and disappears soon after fusion is complete. Expand
Mitochondrial Fusion in Yeast Requires the Transmembrane GTPase Fzo1p
TLDR
It is proposed that the fuzzy onions family of transmembrane GTPases act as molecular switches to regulate a key step in mitochondrial membrane docking and/or fusion. Expand
Monoclonal antibodies specific for an acetylated form of alpha-tubulin recognize the antigen in cilia and flagella from a variety of organisms
TLDR
Seven monoclonal antibodies raised against tubulin from the axonemes of sea urchin sperm flagella recognize an acetylated form of alpha-tubulin present in theAxoneme of a variety of organisms, and may allow us to deduce the role of tubulin acetylation in the structure and function of microtubules in vivo. Expand
Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells
TLDR
Mfn1 appears to be a key player in mediating mitochondrial fusion and morphology in mammalian cells by binding necessary cofactors and interferes with fusion activity of endogenous Mfn1 protein to allow unopposed mitochondrial fission. Expand
Somatic support cells restrict germline stem cell self-renewal and promote differentiation
TLDR
Evidence is presented that support cells surrounding the stem cells restrict self-renewal and control stem cell number by ensuring asymmetric division, and it is proposed that activation of this receptor specifies normal behaviour of somatic support cells. Expand
Assembly of ring canals in the male germ line from structural components of the contractile ring.
TLDR
It is shown that, in males, unlike females, the fusome persists and enlarges following cessation of the mitotic divisions, developing additional branches during meiosis. Expand
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