M. Fukuma

Publications48
h-index14
Citations1,079
Highly Influential Citations61
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WFS1 Is a Novel Component of the Unfolded Protein Response and Maintains Homeostasis of the Endoplasmic Reticulum in Pancreatic β-Cells*
In Wolfram syndrome, a rare form of juvenile diabetes, pancreatic β-cell death is not accompanied by an autoimmune response. Although it has been reported that mutations in the WFS1 gene are… Expand
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Analysis of the galactose signal transduction pathway in Saccharomyces cerevisiae: interaction between Gal3p and Gal80p.
The GAL3 gene plays a critical role in galactose induction of the GAL genes that encode galactose- metabolizing enzymes in Saccharomyces cerevisiae. Defects in GAL3 result in a long delay in GAL gene… Expand
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Prognostic significance of race and tumor size in carcinosarcoma of gallbladder: a meta-analysis of 68 cases.
Carcinosarcoma of gallbladder, also named sarcomatoid carcinoma and spindle cell carcinoma, is a rare neoplasm. Its clinical features and prognostic determinants are still poorly understood due to… Expand
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma
The chromosomal translocation specifically linked to the Ewing sarcoma family results in the generation of fusion proteins comprising the amino terminal portion of EWS and the DNA-binding domain of… Expand
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Overexpression of leucine‐rich repeat‐containing G protein‐coupled receptor 5 in colorectal cancer
Leucine‐rich repeat‐containing G protein‐coupled receptor 5 (LGR5) is a 7‐transmembrane receptor reportedly expressed in stem cells of the intestinal crypts and hair follicles of mice. Overexpression… Expand
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Synuclein-γ Is Closely Involved in Perineural Invasion and Distant Metastasis in Mouse Models and Is a Novel Prognostic Factor in Pancreatic Cancer
Purpose: Perineural invasion is associated with the high incidence of local recurrence and a dismal prognosis in pancreatic cancer. We previously reported a novel perineural invasion model and… Expand
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G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation.
The significance of Hedgehog (HH) signaling in the development of basal cell carcinoma (BCC) has been established. Although several target genes of HH signaling have been described previously, their… Expand
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Leucine-rich repeat-containing G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular carcinoma cells.
The leucine-rich repeat containing G protein-coupled receptor 5 (LGR5), also known as GPR49, is a seven-transmembrane receptor that is expressed in stem cells of the intestinal crypts and hair… Expand
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Establishment of Perineural Invasion Models and Analysis of Gene Expression Revealed an Invariant Chain (CD74) as a Possible Molecule Involved in Perineural Invasion in Pancreatic Cancer
Purpose: Perineural invasion causes frequent local recurrence even after resection and a poor prognosis for pancreatic cancer. We established perineural invasion models and analyzed the molecular… Expand
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Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo.
Ewing sarcoma is a malignant bone and soft tissue tumor of children and young adults, which is known to be highly aggressive and invasive. It expresses specific chimeric genes (EWS-FLI-1, EWS-ERG,… Expand
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