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The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation.
Endothelium-dependent relaxations are achieved by a combination of endothelium-derived prostacyclin (PGI2), nitric oxide (NO), and endothelium-derived hyperpolarizing factor (EDHF). However, itExpand
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A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.
The temperature-sensitive BHK21 hamster cell line tsBN67 ceases to proliferate at the nonpermissive temperature after a lag of one to a few cell divisions, and the arrested cells display a geneExpand
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Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.
Thiazolidinedione and isoxazolidinedione insulin sensitizers activate peroxisome proliferator-activated receptor gamma (PPAR gamma). Some thiazolidinediones modify ion channels in smooth muscles;Expand
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Decreased endothelium-dependent hyperpolarization to acetylcholine in smooth muscle of the mesenteric artery of spontaneously hypertensive rats.
The endothelium-dependent vascular relaxation to acetylcholine (ACh) in spontaneously hypertensive rats (SHR) may be impaired because of an imbalance of endothelium-derived relaxing factor andExpand
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TGF-beta 1 in glomerulosclerosis and interstitial fibrosis of adriamycin nephropathy.
The role of transforming growth factor-beta 1 (TGF-beta 1) for renal injury was investigated in the chronic model of progressive renal disease in rats induced by the injection of adriamycin. TheExpand
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Seasonal variation in stroke incidence in Hisayama, Japan.
We investigated seasonal variation in the incidence of cerebral stroke among the general population aged greater than or equal to 40 years in November of 1961 in Hisayama, Japan. During the 24-yearExpand
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Prevalence and Etiology of Dementia in a Japanese Community
Background and Purpose We sought to determine the type-specific prevalence of dementia and its risk factors in elderly persons from the Japanese community of Hisayama. Methods We studied theExpand
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Age and Hypertension Promote Endothelium‐Dependent Contractions to Acetylcholine in the Aorta of the Rat
This study was undertaken to compare age-related changes in endothelium-dependent vascular responses in both hypertensive and normotensive rats. Aorta from normotensive Wistar-Kyoto (WKY) rats andExpand
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Incidence and Risk Factors for Subtypes of Cerebral Infarction in a General Population: The Hisayama Study
Background and Purpose We estimated the incidence of first-ever cerebral infarction in regard to its subtypes and analyzed their risk factors separately in a community-based prospective cohort studyExpand
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Prevalence of intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy series during a 30-year observation period. The Hisayama study.
BACKGROUND AND PURPOSE Subarachnoid hemorrhage is a life-threatening disease that occurs mostly because of the rupture of intracranial saccular aneurysms. However, little is known about theExpand
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