Author pages are created from data sourced from our academic publisher partnerships and public sources.
The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation.
- H. Shimokawa, H. Yasutake, +8 authors A. Takeshita
- Journal of cardiovascular pharmacology
- 1 November 1996
Endothelium-dependent relaxations are achieved by a combination of endothelium-derived prostacyclin (PGI2), nitric oxide (NO), and endothelium-derived hyperpolarizing factor (EDHF). However, it… Expand
A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.
The temperature-sensitive BHK21 hamster cell line tsBN67 ceases to proliferate at the nonpermissive temperature after a lag of one to a few cell divisions, and the arrested cells display a gene… Expand
Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.
- K. Eto, Y. Ohya, Y. Nakamura, I. Abe, M. Fujishima
- Biology, Medicine
- European journal of pharmacology
- 29 June 2001
Thiazolidinedione and isoxazolidinedione insulin sensitizers activate peroxisome proliferator-activated receptor gamma (PPAR gamma). Some thiazolidinediones modify ion channels in smooth muscles;… Expand
Decreased endothelium-dependent hyperpolarization to acetylcholine in smooth muscle of the mesenteric artery of spontaneously hypertensive rats.
The endothelium-dependent vascular relaxation to acetylcholine (ACh) in spontaneously hypertensive rats (SHR) may be impaired because of an imbalance of endothelium-derived relaxing factor and… Expand
TGF-beta 1 in glomerulosclerosis and interstitial fibrosis of adriamycin nephropathy.
- K. Tamaki, S. Okuda, T. Ando, T. Iwamoto, M. Nakayama, M. Fujishima
- Biology, Medicine
- Kidney international
- 1 February 1994
The role of transforming growth factor-beta 1 (TGF-beta 1) for renal injury was investigated in the chronic model of progressive renal disease in rats induced by the injection of adriamycin. The… Expand
Seasonal variation in stroke incidence in Hisayama, Japan.
We investigated seasonal variation in the incidence of cerebral stroke among the general population aged greater than or equal to 40 years in November of 1961 in Hisayama, Japan. During the 24-year… Expand
Prevalence and Etiology of Dementia in a Japanese Community
Background and Purpose We sought to determine the type-specific prevalence of dementia and its risk factors in elderly persons from the Japanese community of Hisayama. Methods We studied the… Expand
Age and Hypertension Promote Endothelium‐Dependent Contractions to Acetylcholine in the Aorta of the Rat
- T. Koga, Y. Takata, K. Kobayashi, S. Takishita, Y. Yamashita, M. Fujishima
- 1 November 1989
This study was undertaken to compare age-related changes in endothelium-dependent vascular responses in both hypertensive and normotensive rats. Aorta from normotensive Wistar-Kyoto (WKY) rats and… Expand
Incidence and Risk Factors for Subtypes of Cerebral Infarction in a General Population: The Hisayama Study
Background and Purpose We estimated the incidence of first-ever cerebral infarction in regard to its subtypes and analyzed their risk factors separately in a community-based prospective cohort study… Expand
Prevalence of intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy series during a 30-year observation period. The Hisayama study.
BACKGROUND AND PURPOSE Subarachnoid hemorrhage is a life-threatening disease that occurs mostly because of the rupture of intracranial saccular aneurysms. However, little is known about the… Expand