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Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population
TLDR
It is suggested that asymptomatic stroke is an important factor in the development of VD, with age, prior stroke episodes, systolic blood pressure, and alcohol consumption being independent risk factors for its occurrence.
The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation.
TLDR
The results indicate that the importance of EDHF increases as the vessel size decreases in endothelium-dependent relaxations in the rat mesenteric circulation.
Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.
TLDR
Three thiazolidinediones and isoxazolidinedione act differently on Ca(2+) and K(+) channels in vascular smooth muscle and involvement of PPAR gamma activation in the stimulation of I(Kca) is possible but should be tested further.
Decreased endothelium-dependent hyperpolarization to acetylcholine in smooth muscle of the mesenteric artery of spontaneously hypertensive rats.
TLDR
It would appear that the endothelium-dependent hyperpolarization to ACh is reduced in SHR and this would, in part, account for the impaired relaxation to A choline inSHR mesenteric arteries.
TGF-beta 1 in glomerulosclerosis and interstitial fibrosis of adriamycin nephropathy.
TLDR
Temporal and spacial relationships between the renal histological changes and the increased expression of TGF-beta 1 and T GF-beta receptors may suggest that TGF -beta 1 plays an important role in the process of the renal fibrosis and sclerosis.
Seasonal variation in stroke incidence in Hisayama, Japan.
TLDR
Subjects less than 64 years of age showed a significant seasonal variation in the incidence of both intracerebral hemorrhage and cerebral infarction, and subjects with hypertension or a high serum cholesterol level showed no significant seasonal pattern.
Prevalence and Etiology of Dementia in a Japanese Community
TLDR
Prevalence of dementia among the Hisayama residents was relatively identical to that previously reported, but vascular dementia was more predominant Risk factors for vascular dementia were similar to those for lacunar infarcts.
Age and Hypertension Promote Endothelium‐Dependent Contractions to Acetylcholine in the Aorta of the Rat
TLDR
The findings suggest that the release of or vascular responsiveness to endothelium-derived relaxing factor in the aorta is well maintained through senescence in both strains and that, in theAorta of not only SHR but also old normotensive WKY rats, the endot Helium releases contracting factors that may be thromboxane A2 and other vasoconstrictor prostanoids.
Incidence and Risk Factors for Subtypes of Cerebral Infarction in a General Population: The Hisayama Study
TLDR
In this Japanese population, lacunar infarction was the most common subtype of cerebralinfarction and had a greater variety of risk factors, including not only hypertension but also ECG abnormalities, diabetes, obesity, and smoking, than did atherothrombotic infarctions or cardioembolic infarition.
Prevalence of intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy series during a 30-year observation period. The Hisayama study.
TLDR
The data suggest that intracranial aneurysms are more frequent in women in the general Japanese population, and are more prevalent in the middle cerebral artery, but the risk of rupture is highest in the vertebrobasilar system.
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