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Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).
Over 10,000 research scientists attended the ICAAC meeting in Toronto, Canada. The continued increase in the rate of resistance in bacteria and fungi and the underlying mechanisms of resistance wereExpand
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98th General Meeting of the American Society for Microbiology. May 17-21, 1998; Atlanta, GA.
: The 98th General Meeting of the American Society for Microbiology was held from May 17-21, 1998, in Atlanta, Georgia and was attended by well over 10,000 scientists. The theme of antibioticExpand
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Antibacterial agents that inhibit two-component signal transduction systems.
A class of antibacterials has been discovered that inhibits the growth of Gram-positive pathogenic bacteria. RWJ-49815, a representative of a family of hydrophobic tyramines, in addition to being aExpand
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Comparison of the postantibiotic and postantibiotic sub-MIC effects of levofloxacin and ciprofloxacin on Staphylococcus aureus and Streptococcus pneumoniae.
The postantibiotic subminimum inhibitory concentration effect (PA SME) may simulate in vivo drug exposure more accurately than the postantibiotic effect (PAE) since subinhibitory concentrations ofExpand
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Purification and properties of the elastase from Aspergillus fumigatus.
Elastase, a potential virulence factor from the opportunistic pathogen Aspergillus fumigatus, was purified 220-fold from culture broth by fast-performance liquid chromatography employing anionExpand
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Conserved Fungal Genes as Potential Targets for Broad-Spectrum Antifungal Drug Discovery
ABSTRACT The discovery of novel classes of antifungal drugs depends to a certain extent on the identification of new, unexplored targets that are essential for growth of fungal pathogens. Likewise,Expand
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Comparison of Efficacies of Oral Levofloxacin and Oral Ciprofloxacin in a Rabbit Model of a Staphylococcal Abscess
ABSTRACT Oral levofloxacin was compared to oral ciprofloxacin in aStaphylococcus aureus subcutaneous abscess model in rabbits. Rabbits were surgically prepared with subcutaneous wiffle balls (43 mmExpand
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Bactericidal Activities of BMS-284756, a Novel Des-F(6)-Quinolone, against Staphylococcus aureus Strains with Topoisomerase Mutations
ABSTRACT The antistaphylococcal activities of BMS-284756 (T-3811ME), levofloxacin, moxifloxacin, and ciprofloxacin were compared against wild-type and grlA and grlA/gyrA mutant strains ofExpand
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Importance of antifungal drug-resistance: clinical significance and need for novel therapy.
The incidence of fungal infections has increased dramatically over the past few decades due to the increase in the members of the population susceptible to such infections. This population includesExpand
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Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials.
A series of potential antimicrobial derivatives possessing bioisosteric replacements for the central oxazolidinone ring found in oxazolidinone antibacterials have been prepared. The design conceptExpand
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