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CpG islands in vertebrate genomes.
It is shown that CpG islands in methylated genomes are maintained, despite a tendency for 5mCpG to mutate by deamination to TpG+CpA, by the structural stability of a high G+C content alone, and that C pG islands associated with exons result from some selective importance of the arginine codon CGX. Expand
A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.
- M. Frommer, L. E. McDonald, +5 authors C. Paul
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 March 1992
A genomic sequencing method is reported that provides positive identification of 5-methylcytosine residues and yields strand-specific sequences of individual molecules in genomic DNA, which suggests that the high methylation level of single-copy sequences in sperm may be locally modulated by binding of protein factors in germ-line cells. Expand
High sensitivity mapping of methylated cytosines.
A genomic sequencing technique which is capable of detecting every methylated cytosine on both strands of any target sequence, using DNA isolated from fewer than 100 cells is developed. Expand
A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA
Genomic mapping of three nonribosomal fragments showed that they are part of islands of DNA within which nonmethylated Hpa II and Hha I sites are highly concentrated, estimating about 30,000 islands per haploid genome and discussing evidence that many may be associated with genes. Expand
Sequence relationships of three human satellite DNAs.
- J. Prosser, M. Frommer, C. Paul, P. Vincent
- Physics, Medicine
- Journal of molecular biology
- 20 January 1986
The simple sequence components of three human classical satellite DNAs have been defined, and some segments of each satellite have been sequenced, and analysis of satellite 2 sequences suggested that the five base-pair repeat was originally amplified as a higher-order repeat like that of satellite 3. Expand
Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors.
The dynamics of DNA methylation in cancer cells are clearly different from normal cells and an insight into the mechanism of abnormal methylation of CpG islands incancer cells is given. Expand
The Bactrocera tryoni homologue of the Drosophila melanogaster sex‐determination gene doublesex
A homologue of the bifunctional sex‐determining gene, doublesex (dsx), has been identified in the tephritid fruit fly, Bactrocera tryoni, and has been found to be expressed in a sex‐specific manner… Expand
Tropical tephritid fruit fly community with high incidence of shared Wolbachia strains as platform for horizontal transmission of endosymbionts.
- J. Morrow, M. Frommer, D. Shearman, M. Riegler
- Biology, Medicine
- Environmental microbiology
- 1 December 2014
An unprecedented high incidence of four shared Wolbachia strains in eight host species from two trophic levels is reported, suggesting frequent exposure to WolbachIA in this tropical tephritid community that shares host plant and parasitoid species, and also includes species that hybridize. Expand
Mitotic and polytene chromosome analyses in the Queensland fruit fly, Bactrocera tryoni (Diptera: Tephritidae).
Chromosomal homology between B. tryoni and C. capitata has been determined by comparing chromosome banding pattern and in situ hybridisation of cloned genes to polytene chromosomes. Expand
The draft genome of the pest tephritid fruit fly Bactrocera tryoni: resources for the genomic analysis of hybridising species
A draft de novo genome assembly of Australia’s major tephritid pest species, Bactrocera tryoni, is produced, showing how whole genome sequence data can be used to generate simple diagnostic tests between very closely-related species where only one of the species is scaffolded. Expand