• Publications
  • Influence
Complex phenotype of mice lacking occludin, a component of tight junction strands.
Occludin is an integral membrane protein with four transmembrane domains that is exclusively localized at tight junction (TJ) strands. Here, we describe the generation and analysis of mice carrying aExpand
  • 992
  • 44
  • PDF
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells
Tight junctions seal the paracellular pathway of epithelia but, in leaky tissues, also exhibit specific permeability. In order to characterize the contribution of claudin-2 to barrier andExpand
  • 653
  • 31
  • PDF
Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution.
BACKGROUND & AIMS Ulcerative colitis (UC) is characterized by a Th2 immune response with inflammation and epithelial barrier dysfunction. So far, Th2 cytokines have not been shown to directlyExpand
  • 898
  • 31
E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
Cadherin adhesion molecules are key determinants of morphogenesis and tissue architecture. Nevertheless, the molecular mechanisms responsible for the morphogenetic contributions of cadherins remainExpand
  • 385
  • 29
  • PDF
Claudins and other tight junction proteins.
Epithelial transport relies on the proper function and regulation of the tight junction (TJ), other-wise uncontrolled paracellular leakage of solutes and water would occur. They also act as a fenceExpand
  • 207
  • 19
Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis.
BACKGROUND & AIMS Mechanisms of diarrhea in ulcerative colitis (UC) are still unknown. Functional and structural characterization of epithelial barrier and transport properties in ulcerative colitisExpand
  • 498
  • 14
Epithelial Tight Junctions in Intestinal Inflammation
The epithelium in inflamed intestinal segments of patients with Crohn's disease is characterized by a reduction of tight junction strands, strand breaks, and alterations of tight junction proteinExpand
  • 290
  • 14
Claudin-2, a component of the tight junction, forms a paracellular water channel
Whether or not significant amounts of water pass the tight junction (TJ) of leaky epithelia is still unresolved, because it is difficult to separate transcellular water flux from TJ-controlledExpand
  • 290
  • 14
  • PDF
Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6.
Cytokines are supposed to be mediators in diarrhoeal diseases. The aim of this study is to characterize the effect of tumor necrosis factor-alpha (TNFalpha) on epithelial barrier function in theExpand
  • 342
  • 11
Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability.
Tricellulin is a tight junction protein localized in tricellular tight junctions (tTJs), the meeting points of three cells, but also in bicellular tight junctions (bTJs). To investigate its specificExpand
  • 256
  • 10
  • PDF