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Activity-dependent neurotrophic factor: structure-activity relationships of femtomolar-acting peptides.
ADNF-9, like ADNF-14, was neuroprotective against N-methyl-D-aspartate and the beta-amyloid peptide (amino acids 25-35), and had a much broader range of effective concentrations than AD NF-14. Expand
Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Tumor Necrosis Factor α Transcriptional Activation by Regulating Nuclear Factor-kB and cAMP Response
Because TNFα plays a central role in various inflammatory diseases such as endotoxic shock, multiple sclerosis, cerebral malaria, and various autoimmune conditions, the down-regulatory effect of VIP/PACAP may have a significant therapeutic potential. Expand
Bacterial induction of autoantibodies to beta2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome.
A mechanism of molecular mimicry in experimental APS is established, demonstrating that bacterial peptides homologous with beta2GPI induce pathogenic anti-beta2G PI Ab's along with APS manifestations. Expand
IL-2 induces T cell adherence to extracellular matrix: inhibition of adherence and migration by IL-2 peptides generated by leukocyte elastase.
It is reported that IL-2 enhances human T cell adherence to laminin, collagen type IV, and fibronectin (FN) and may serve as natural feedback inhibitors of inflammation. Expand
Growth factor function of vasoactive intestinal peptide in whole cultured mouse embryos
It is suggested that VIP acts as a growth factor on early postimplantation embryos through multiple VIP receptors that exhibit tissue-specific responses that were differentially regulated in VIP antagonist-treated embryos. Expand
All‐D‐magainin: chirality, antimicrobial activity and proteolytic resistance
All‐D‐magainin‐2 was synthesized to corroborate experimentally the notion that the biological function of a surface‐active peptide stems primarily from its unique amphiphilic α ‐helical structure.Expand
CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma
This work uses total acid extraction and repeated fractionation to isolate and sequence Lewis lung carcinoma (3LL)-specific peptide(s), which shows sequence homology to the connexin 37 protein. Expand
Enhancement of phagocytosis - a newly found activity of substance P residing in its N-terminal tetrapeptide sequence.
The phagocytosis-enhancing activity of Substance P may play a role in inflammatory processes of neural origin where the involvement of the peptide has been implicated. Expand
Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria.
The present study further increases the understanding of the complex PMBN-LPS and may, potentially, enable the design of compounds having enhanced permeabilization potency of the Gram-negative outer membrane. Expand
The Binding Site of Acetylcholine Receptor as Visualized in the X-Ray Structure of a Complex between α-Bungarotoxin and a Mimotope Peptide
The superposition indicates that the toxin wraps around the receptor binding site loop, and in addition, binds tightly at the interface of two of the receptor subunits where it inserts a finger into the ligand binding site, thus blocking access to the acetylcholine binding site and explaining its strong antagonistic activity. Expand