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HDLs Protect Pancreatic β-Cells Against ER Stress by Restoring Protein Folding and Trafficking
Endoplasmic reticulum (ER) homeostasis alteration contributes to pancreatic β-cell dysfunction and death and favors the development of diabetes. In this study, we demonstrate that HDLs protectExpand
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Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy.
OBJECTIVE The purpose of this study was to investigate whether prostaglandin E2 (PGE2) induces Signal transducer and activator of transcription 3 (Stat3) activation in neonatal rat ventricularExpand
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New insights into the molecular basis of desmoplakinand desmin-related cardiomyopathies
Desmosomes are intercellular adhesive complexes that anchor the intermediate filament cytoskeleton to the cell membrane in epithelia and cardiac muscle cells. The desmosomal component desmoplakinExpand
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High density lipoprotein / sphingosine-1-phosphate-induced cardioprotection : Role of STAT 3 as part of the SAFE pathway
High density lipoprotein (HDL) cholesterol has beneficial effects beyond its atheroprotective function in reverse cholesterol transport, including cardioprotection against ischemia reperfusion (IR)Expand
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Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate.
AIMS High-density lipoprotein (HDL) has been reported to have cardioprotective properties independent from its cholesterol transport activity. The influence of native HDL and reconstituted HDL (rHDL)Expand
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Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis.
AIMS We analysed the impact of native and reconstituted HDL on doxorubicin-induced cardiomyocyte apoptosis. While it is an effective anti-cancer agent, doxorubicin has serious cardiotoxic sideExpand
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Plectin interacts with the rod domain of type III intermediate filament proteins desmin and vimentin.
Plectin is a versatile cytolinker protein critically involved in the organization of the cytoskeletal filamentous system. The muscle-specific intermediate filament (IF) protein desmin, whichExpand
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Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution
BackgroundObesity and low high-density lipoprotein-cholesterol (HDL-C) levels are associated with cardiovascular risk. Surprisingly, despite a greater prevalence of obesity and lower HDLExpand
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HDL protects against myocardial ischemia reperfusion injury via miR-34b and miR-337 expression which requires STAT3
Purpose High density lipoprotein (HDL) protects against myocardial infarction via mechanisms that remain unclear. STAT3 (signal transducer and activator of transcription 3) plays a key role inExpand
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Interplay Between SAFE and RISK Pathways in Sphingosine-1-Phosphate–Induced Cardioprotection
PurposeWe studied the role of two powerful molecular signalling mechanisms involved in the cardioprotective effect of sphingosine-1-phosphate (S1P), a major component of high density lipoproteinExpand
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