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HDLs Protect Pancreatic β-Cells Against ER Stress by Restoring Protein Folding and Trafficking
Endoplasmic reticulum (ER) homeostasis alteration contributes to pancreatic β-cell dysfunction and death and favors the development of diabetes. In this study, we demonstrate that HDLs protect… Expand
Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy.
OBJECTIVE The purpose of this study was to investigate whether prostaglandin E2 (PGE2) induces Signal transducer and activator of transcription 3 (Stat3) activation in neonatal rat ventricular… Expand
New insights into the molecular basis of desmoplakinand desmin-related cardiomyopathies
- K. Lapouge, L. Fontao, +6 authors L. Borradori
- Medicine, Biology
- Journal of Cell Science
- 1 December 2006
Desmosomes are intercellular adhesive complexes that anchor the intermediate filament cytoskeleton to the cell membrane in epithelia and cardiac muscle cells. The desmosomal component desmoplakin… Expand
High density lipoprotein / sphingosine-1-phosphate-induced cardioprotection : Role of STAT 3 as part of the SAFE pathway
High density lipoprotein (HDL) cholesterol has beneficial effects beyond its atheroprotective function in reverse cholesterol transport, including cardioprotection against ischemia reperfusion (IR)… Expand
Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate.
AIMS High-density lipoprotein (HDL) has been reported to have cardioprotective properties independent from its cholesterol transport activity. The influence of native HDL and reconstituted HDL (rHDL)… Expand
Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis.
AIMS We analysed the impact of native and reconstituted HDL on doxorubicin-induced cardiomyocyte apoptosis. While it is an effective anti-cancer agent, doxorubicin has serious cardiotoxic side… Expand
Plectin interacts with the rod domain of type III intermediate filament proteins desmin and vimentin.
- B. Favre, Y. Schneider, +7 authors L. Fontao
- Medicine, Biology
- European journal of cell biology
- 1 May 2011
Plectin is a versatile cytolinker protein critically involved in the organization of the cytoskeletal filamentous system. The muscle-specific intermediate filament (IF) protein desmin, which… Expand
Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution
- Nicholas J. Woudberg, Julia H. Goedecke, +4 authors S. Lecour
- Lipids in Health and Disease
- 11 May 2016
BackgroundObesity and low high-density lipoprotein-cholesterol (HDL-C) levels are associated with cardiovascular risk. Surprisingly, despite a greater prevalence of obesity and lower HDL… Expand
HDL protects against myocardial ischemia reperfusion injury via miR-34b and miR-337 expression which requires STAT3
- Sarah Pedretti, M. Brulhart-Meynet, F. Montecucco, S. Lecour, R. James, M. Frias
- PloS one
- 20 June 2019
Purpose High density lipoprotein (HDL) protects against myocardial infarction via mechanisms that remain unclear. STAT3 (signal transducer and activator of transcription 3) plays a key role in… Expand
Interplay Between SAFE and RISK Pathways in Sphingosine-1-Phosphate–Induced Cardioprotection
- Sarin J. Somers, M. Frias, L. Lacerda, Lionel H. Opie, S. Lecour
- Cardiovascular Drugs and Therapy
- 6 March 2012
PurposeWe studied the role of two powerful molecular signalling mechanisms involved in the cardioprotective effect of sphingosine-1-phosphate (S1P), a major component of high density lipoprotein… Expand