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Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment
The development and homeostasis of neurons relies heavily on the selective targeting of vesicles into axon and dendrites. Microtubule-based motor proteins play an important role in polarizedExpand
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TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays
Axon formation, the initial step in establishing neuronal polarity, critically depends on local microtubule reorganization and is characterized by the formation of parallel microtubule bundles. HowExpand
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Microtubule-based transport – basic mechanisms, traffic rules and role in neurological pathogenesis
Summary Microtubule-based transport is essential for neuronal function because of the large distances that must be traveled by various building blocks and cellular materials. Recent studies inExpand
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KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons
Increased phosphorylation of the KIF5 anterograde motor is associated with impaired axonal transport and neurodegeneration, but paradoxically also with normal transport, though the details are notExpand
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Microtubule Plus-End Tracking Proteins SLAIN1/2 and ch-TOG Promote Axonal Development
Development, polarization, structural integrity, and plasticity of neuronal cells critically depend on the microtubule network and its dynamic properties. SLAIN1 and SLAIN2 are microtubule plus-endExpand
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Three-Step Model for Polarized Sorting of KIF17 into Dendrites
Kinesin and dynein motors drive bidirectional cargo transport along microtubules and have a critical role in polarized cargo trafficking in neurons [1, 2]. The kinesin-2 family protein KIF17 is aExpand
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Visualisations in science communication: Friend or foe?