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Dual-surface modification of the tobacco mosaic virus.
The protein shell of the tobacco mosaic virus (TMV) provides a robust and practical tubelike scaffold for the preparation of nanoscale materials. To expand the range of applications for which theExpand
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Dual-surface modified virus capsids for targeted delivery of photodynamic agents to cancer cells.
Bacteriophage MS2 was used to construct a targeted, multivalent photodynamic therapy vehicle for the treatment of Jurkat leukemia T cells. The self-assembling spherical virus capsid was modified onExpand
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High relaxivity gadolinium hydroxypyridonate-viral capsid conjugates: nanosized MRI contrast agents.
High relaxivity macromolecular contrast agents based on the conjugation of gadolinium chelates to the interior and exterior surfaces of MS2 viral capsids are assessed. The proton nuclear magneticExpand
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Self-assembling light-harvesting systems from synthetically modified tobacco mosaic virus coat proteins.
A new protein-based approach has been developed for the construction of light-harvesting systems through self-assembly. The building blocks were prepared by attaching fluorescent chromophores toExpand
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Interior surface modification of bacteriophage MS2.
An efficient strategy for the interior surface functionalization of MS2 viral capsids is reported, featuring a new hetero-Diels-Alder bioconjugation reaction. After virus isolation, the RNA genomeExpand
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Integrated microfluidic bioprocessor for single-cell gene expression analysis
An integrated microdevice is developed for the analysis of gene expression in single cells. The system captures a single cell, transcribes and amplifies the mRNA, and quantitatively analyzes theExpand
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Osmolyte-mediated encapsulation of proteins inside MS2 viral capsids.
The encapsulation of enzymes in nanometer-sized compartments has the potential to enhance and control enzymatic activity, both in vivo and in vitro. Despite this potential, there is littleExpand
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Viral capsid DNA aptamer conjugates as multivalent cell-targeting vehicles.
Nucleic acid aptamers offer significant potential as convenient and evolvable targeting groups for drug delivery. To attach them to the surface of a genome-free viral capsid carrier, an efficientExpand
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Targeting the N terminus for site-selective protein modification.
The formation of well-defined protein bioconjugates is critical for many studies and technologies in chemical biology. Tried-and-true methods for accomplishing this typically involve the targeting ofExpand
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